Genedani S, Bernardi M, Tagliavini S, Botticelli A, Bertolini A
Institute of Pharmacology, University of Modena, Italy.
Pharmacol Toxicol. 1987 Oct;61(4):224-7. doi: 10.1111/j.1600-0773.1987.tb01808.x.
In untreated rats, the intraperitoneal injection of putrescine evoked a typical wet-dog shake response, that was maximal at a dose of 300 mg/kg and at room temperature (22 degrees) (number of shakes: 84.00 +/- 17.90/hr). In a hot environment (30 degrees) the number of shakes was markedly reduced (26.90 +/- 5.19/hr). The putrescine-induced shaking behaviour was unaffected by atropine, bicuculline, chlorpheniramine, cimetidine, methysergide, naloxone and noradrenaline, but was markedly antagonized by morphine. Naloxone pretreatment nullified the antagonistic activity of morphine. Histological studies showed marked alterations in brain vascular permeability, which was increased by putrescine. Morphine completely prevented this putrescine-induced vascular effect. These results suggest a correlation between WDS produced by putrescine and increase in brain vascular permeability. Furthermore they show that morphine can affect brain vascular permeability.
在未处理的大鼠中，腹腔注射腐胺可引发典型的湿狗样抖动反应，在剂量为300mg/kg且室温（22摄氏度）时反应最为强烈（抖动次数：84.00±17.90次/小时）。在炎热环境（30摄氏度）中，抖动次数显著减少（26.90±5.19次/小时）。腐胺诱导的抖动行为不受阿托品、荷包牡丹碱、氯苯那敏、西咪替丁、甲基麦角新碱、纳洛酮和去甲肾上腺素的影响，但吗啡可显著拮抗该行为。纳洛酮预处理可消除吗啡的拮抗活性。组织学研究显示脑血管通透性有明显改变，腐胺可使其增加。吗啡可完全阻止腐胺诱导的血管效应。这些结果表明腐胺产生的湿狗样抖动与脑血管通透性增加之间存在关联。此外，它们还表明吗啡可影响脑血管通透性。
