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通过Ti6Al4V合金表面低电位阳极氧化制备的二氧化钛纳米管涂层的生物活性和光催化性能

The Bioactivity and Photocatalytic Properties of Titania Nanotube Coatings Produced with the Use of the Low-Potential Anodization of Ti6Al4V Alloy Surface.

作者信息

Radtke Aleksandra, Topolski Adrian, Jędrzejewski Tomasz, Kozak Wiesław, Sadowska Beata, Więckowska-Szakiel Marzena, Szubka Magdalena, Talik Ewa, Pleth Nielsen Lars, Piszczek Piotr

机构信息

Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarina 7, 87-100 Toruń, Poland.

Nano-Implant Ltd. Gagarina 5, 87-100 Toruń, Poland.

出版信息

Nanomaterials (Basel). 2017 Jul 26;7(8):197. doi: 10.3390/nano7080197.

DOI:10.3390/nano7080197
PMID:28933732
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5575679/
Abstract

Titania nanotube (TNT) coatings were produced using low-potential anodic oxidation of Ti6Al4V substrates in the potential range 3-20 V. They were analysed by X-ray diffraction (XRD), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). The wettability was estimated by measuring the contact angle when applying water droplets. The bioactivity of the TNT coatings was established on the basis of the biointegration assay (L929 murine fibroblasts adhesion and proliferation) and antibacterial tests against (ATCC 29213). The photocatalytic efficiency of the TNT films was studied by the degradation of methylene blue under UV irradiation. Among the studied coatings, the TiO₂ nanotubes obtained with the use of 5 V potential (TNT5) were found to be the most appropriate for medical applications. The TNT5 sample possessed antibiofilm properties without enriching it by additional antimicrobial agent. Furthermore, it was characterized by optimal biocompatibility, performing better than pure Ti6Al4V alloy. Moreover, the same sample was the most photocatalytically active and exhibited the potential for the sterilization of implants with the use of UV light and for other environmental applications.

摘要

通过在3 - 20 V电位范围内对Ti6Al4V基底进行低电位阳极氧化制备了二氧化钛纳米管（TNT）涂层。采用X射线衍射（XRD）、拉曼光谱、X射线光电子能谱（XPS）和扫描电子显微镜（SEM）对其进行分析。通过测量水滴接触角来评估润湿性。基于生物整合试验（L929小鼠成纤维细胞粘附和增殖）以及针对金黄色葡萄球菌（ATCC 29213）的抗菌测试确定了TNT涂层的生物活性。通过在紫外线照射下亚甲基蓝的降解研究了TNT薄膜的光催化效率。在所研究的涂层中，发现使用5 V电位获得的TiO₂纳米管（TNT5）最适合医学应用。TNT5样品具有抗生物膜特性，无需添加额外的抗菌剂。此外，它具有最佳的生物相容性，表现优于纯Ti6Al4V合金。而且，同一样品具有最高的光催化活性，展现出利用紫外线对植入物进行灭菌以及用于其他环境应用的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9427/5575679/23c1cabaf3b1/nanomaterials-07-00197-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9427/5575679/85c5a96c0e8b/nanomaterials-07-00197-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9427/5575679/b110afbf6610/nanomaterials-07-00197-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9427/5575679/23c1cabaf3b1/nanomaterials-07-00197-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9427/5575679/0bc9c96447b8/nanomaterials-07-00197-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9427/5575679/4a2cf02af56a/nanomaterials-07-00197-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9427/5575679/fc04bd9a43a3/nanomaterials-07-00197-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9427/5575679/89c7978ba4f5/nanomaterials-07-00197-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9427/5575679/be437dec21e5/nanomaterials-07-00197-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9427/5575679/85c5a96c0e8b/nanomaterials-07-00197-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9427/5575679/b110afbf6610/nanomaterials-07-00197-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9427/5575679/23c1cabaf3b1/nanomaterials-07-00197-g008.jpg

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