IRIS, Faculty of Engineering and Industrial Sciences, Swinburne University of Technology, Hawthorn, Victoria 3122, Australia.
Acta Biomater. 2012 Aug;8(8):2875-88. doi: 10.1016/j.actbio.2012.04.005. Epub 2012 Apr 25.
Metal implants are the best choice for the long-term replacement of hard tissue, such as hip and knee joints, because of their excellent mechanical properties. Titanium and its alloys, due to their self-organized oxide layer, which protects the surface from corrosion and prevents ion release, are widely accepted as biocompatible metal implants. Surface modification is essential for the promotion of the osseointegration of these biomaterials. Nanotubes fabricated on the surface of metal implants by anodization are receiving ever-increasing attention for surface modification. This paper provides an overview of the employment of anodization for nanotubes fabricated on the surface of titanium, titanium alloys and titanium alloying metals such as niobium, tantalum and zirconium metal implants. This work explains anodic oxidation and the manner by which nanotubes form on the surface of the metals. It then assesses this topical research to indicate how changes in anodizing conditions influence nanotube characteristics such as tube diameters and nanotube-layer thickness.
金属植入物因其优异的机械性能，是长期替代硬组织（如髋关节和膝关节）的最佳选择。由于其自组织氧化层可以保护表面免受腐蚀并防止离子释放，钛及其合金被广泛认为是生物相容性金属植入物。表面改性对于促进这些生物材料的骨整合至关重要。通过阳极氧化在金属植入物表面制造的纳米管在表面改性方面受到越来越多的关注。本文综述了在钛、钛合金以及钛合金金属（如铌、钽和锆）植入物表面制造纳米管时采用阳极氧化的情况。这项工作解释了阳极氧化和金属表面纳米管形成的方式。然后评估了这一热门研究，以表明阳极氧化条件的变化如何影响纳米管的特性，如管直径和纳米管层厚度。
