Pole of Cardiovascular Research (CARD), Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St. Luc, Université Cathologique, Brussels, Belgium.
Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St. Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St., Lambert, Belgium.
J Cardiovasc Magn Reson. 2017 Sep 21;19(1):72. doi: 10.1186/s12968-017-0371-5.
Myocardial T1, T2 and T2* imaging techniques become increasingly used in clinical practice. While normal values for T1, T2 and T2* times are well established for 1.5 Tesla (T) cardiovascular magnetic resonance (CMR), data for 3T remain scarce. Therefore we sought to determine normal reference values relative to gender and age and day to day reproducibility for native T1, T2, T2* mapping and extracellular volume (ECV) at 3T in healthy subjects.
After careful exclusion of cardiovascular abnormality, 75 healthy subjects aged 20 to 90 years old (mean 56 ± 19 years, 47% women) underwent left-ventricular T1 (3-(3)-3-(3)-5 MOLLI)), T2 (8 echo- spin echo-imaging) and T2 * (8 echo gradient echo imaging) mapping at 3T CMR (Philips Ingenia 3T and computation of extracellular volume after administration of 0.2 mmol/kg Gadovist). Inter- and intra-observer reproducibility was estimated by intraclass correlation coefficient (ICC). Day to day reproducibility was assessed in 10 other volunteers.
Mean myocardial T1 at 3T was 1122 ± 57 ms, T2 52 ± 6 ms, T2* 24 ± 5 ms and ECV 26.6 ± 3.2%. T1 (1139 ± 37 vs 1109 ± 73 ms, p < 0.05) and ECV (28 ± 3 vs 25 ± 2%, p < 0.001), but not T2 (53 ± 8 vs 51 ± 4, p = NS) were significantly greater in age matched women than in men. T1 (r = 0.40, p < 0.001) and ECV (r = 0.37, p = 0.001) increased, while T2 decreased significantly (r = -0.25, p < 0.05) with increasing age. T2* was not influenced by either gender or age. Intra and inter-observer reproducibility was high (ICC ranging between 0.81-0.99), and day to day coefficient of variation was low (6.2% for T1, 7% for T2, 11% for T2* and 11.5% for ECV).
We provide normal myocardial T2, T2*,T1 and ECV reference values for 3T CMR which are significantly different from those reported at 1.5 Tesla CMR. Myocardial T1 and ECV values are gender and age dependent. Measurement had high inter and intra-observer reproducibility and good day-to-day reproducibility.
心肌 T1、T2 和 T2成像技术在临床实践中越来越多地被使用。虽然 1.5 特斯拉（T）心血管磁共振（CMR）的 T1、T2 和 T2时间的正常数值已经得到很好的确立，但 3T 的数据仍然很少。因此，我们试图确定相对于性别和年龄的正常参考值，以及在 3T 下健康受试者的原生 T1、T2、T2*映射和细胞外体积（ECV）的日间可重复性。
在仔细排除心血管异常后，75 名年龄在 20 至 90 岁之间（平均 56±19 岁，47%为女性）的健康受试者在 3T CMR（飞利浦 Ingenia 3T）上进行左心室 T1（3-(3)-3-(3)-5 MOLLI））、T2（8 个回波-自旋回波成像）和 T2*（8 个回波梯度回波成像）映射，并计算细胞外体积（在给予 0.2mmol/kg 钆喷酸葡胺后）。通过组内相关系数（ICC）评估观察者内和观察者间的可重复性。另外 10 名志愿者评估了日间可重复性。
3T 时心肌 T1 的平均值为 1122±57ms，T2 为 52±6ms，T2为 24±5ms，ECV 为 26.6±3.2%。T1（1139±37 与 1109±73ms，p<0.05）和 ECV（28±3 与 25±2%，p<0.001）在年龄匹配的女性中明显高于男性，但 T2（53±8 与 51±4，p=NS）则不然。T1（r=0.40，p<0.001）和 ECV（r=0.37，p=0.001）随着年龄的增长而显著增加，而 T2 则显著降低（r=-0.25，p<0.05）。T2不受性别或年龄的影响。观察者内和观察者间的可重复性很高（ICC 范围在 0.81-0.99 之间），日间变异系数很低（T1 为 6.2%，T2 为 7%，T2*为 11%，ECV 为 11.5%）。
我们提供了 3T CMR 心肌 T2、T2*、T1 和 ECV 的正常参考值，这些值与 1.5T CMR 报道的参考值有显著差异。心肌 T1 和 ECV 值与性别和年龄有关。测量具有很高的观察者内和观察者间的可重复性和良好的日间可重复性。
