Department of Radiology, Ankara Etimesgut Şehit Sait Ertürk State Hospital, Ulubatlı Hasan St., No:5, Etimesgut, İstasyon NBHD, TR-06790, Türkiye.
Department of Radiology, Ankara Training and Research Hospital, Ankara, Türkiye.
Int J Cardiovasc Imaging. 2024 Nov;40(11):2357-2369. doi: 10.1007/s10554-024-03241-5. Epub 2024 Sep 16.
This study examines myocardial T1, T2, and T2* values in a sizable cohort of healthy volunteers, analyzing variations by age, sex, and cardiac segments. It offers a novel approach to defining normal parametric mapping boundaries and represents the first comprehensive study of its kind in Turkey. Our prospective study was conducted between August 2021 and August 2022. Healthy volunteers aged 20-80 were grouped, with at least eight females and eight males per decade. Cardiac MRI examination measured T1 and T2 times in 16 left ventricle segments using parametric mapping techniques on a 1.5 Tesla MRI device. T2* mapping was also performed on the mid-section interventricular septum. The data analysis considered the impact of age, sex, and segments. One hundred eighteen cases were included in the study. Female volunteers observed significantly higher T1, T2, and T2* values than male volunteers. For the T2* and T1 times, significantly lower values were detected in women over 50 than those under 50. It was observed that the Midventricular approach (middle section) gave closer results than the Midventricular Septal approach (septal region of middle section) in predicting Global times. We present the normal reference ranges for cardiac T1, T2, and T2* times in a large cohort of healthy volunteers with homogeneous sex and age distribution. Sex was the most influential factor in our study. Therefore, we suggest using separate reference values for males, and females above and below 50 years old, instead of the standard reference intervals that do not account for specified sex in current guidelines.
这项研究检查了相当数量的健康志愿者的心肌 T1、T2 和 T2* 值，分析了年龄、性别和心脏节段的变化。它提供了一种定义正常参数映射边界的新方法，代表了土耳其首例此类全面研究。我们的前瞻性研究于 2021 年 8 月至 2022 年 8 月进行。将年龄在 20-80 岁之间的健康志愿者分组，每个十年至少有 8 名女性和 8 名男性。心脏 MRI 检查使用参数映射技术在 1.5T MRI 设备上测量 16 个左心室节段的 T1 和 T2 时间。还在中隔室的中部进行了 T2映射。数据分析考虑了年龄、性别和节段的影响。本研究共纳入 118 例病例。女性志愿者的 T1、T2 和 T2 值明显高于男性志愿者。对于 T2和 T1 时间，50 岁以上女性的检测值明显低于 50 岁以下女性。观察到 Midventricular 方法（中部）在预测 Global 时间方面比 Midventricular Septal 方法（中部的中隔区）更接近结果。我们在性别和年龄分布均匀的大量健康志愿者中提出了心脏 T1、T2 和 T2时间的正常参考范围。在我们的研究中，性别是最具影响力的因素。因此，我们建议使用男性和 50 岁以上女性的单独参考值，而不是当前指南中不考虑特定性别的标准参考区间。
