Research and Development Department, Matsutani Chemical Industry Co., Ltd., Hyogo, Japan.
Research and Development Department, Matsutani Chemical Industry Co., Ltd., Hyogo, Japan.
Nutrition. 2017 Nov-Dec;43-44:16-20. doi: 10.1016/j.nut.2017.06.007. Epub 2017 Jul 6.
d-Allulose, a C-3 epimer of d-fructose, has been reported to decrease body weight and adipose tissue weight in animal studies and is expected to be a potent antiobese sweetener. Our animal study suggested that one of the mechanisms of d-allulose's antiobesity function is an increase in energy expenditure. However, a few studies have thus far explored the underlying mechanism in humans. The aim of this study was to examine the effects of a single ingestion of d-allulose on postprandial energy metabolism in healthy participants.
Thirteen healthy men and women (mean age of 35.7 ± 2.1 y and body mass index 20.9 ± 0.7 kg/m) were studied. The study was a randomized, single-blind crossover design with a 1-wk washout period. At 30 min after taking 5 g of d-allulose or 10 mg of aspartame without any sugar as a control, overnight-fasted participants ingested a standardized meal, and energy metabolism was evaluated by a breath-by-breath method. During the experiment, blood was collected and biochemical parameters such as plasma glucose were analyzed.
In the d-allulose-treated group, the area under the curve of fat oxidation was significantly higher than in the control group (10.5 ± 0.4 versus 9.6 ± 0.3 kJ·4 h·kg body weight [BW]; P < 0.05), whereas that of carbohydrate oxidation was significantly lower (8.1 ± 0.5 versus 9.2 ± 0.5 kJ·4 h·kg BW; P < 0.05). Furthermore, plasma glucose levels were significantly lower, and free fatty acid levels were significantly higher in the d-allulose group than in the control group. No other parameters such as insulin, total cholesterol, or triacylglycerol were modified.
d-Allulose enhances postprandial fat oxidation in healthy humans, indicating that it could be a novel sweetener to control and maintain healthy body weight, probably through enhanced energy metabolism.
d-阿洛酮糖是 d-果糖的 C-3 差向异构体，已被报道可降低动物研究中的体重和脂肪组织重量，预计是一种有效的抗肥胖甜味剂。我们的动物研究表明，d-阿洛酮糖的抗肥胖功能机制之一是增加能量消耗。然而，迄今为止，只有少数研究在人类中探讨了其潜在机制。本研究旨在研究单次摄入 d-阿洛酮糖对健康参与者餐后能量代谢的影响。
研究纳入 13 名健康男性和女性（平均年龄 35.7±2.1 岁，体重指数 20.9±0.7kg/m）。该研究采用随机、单盲交叉设计，洗脱期为 1 周。在服用 5g d-阿洛酮糖或 10mg 阿斯巴甜（不含任何糖作为对照）后 30 分钟，禁食一夜的参与者摄入标准化餐食，并通过呼吸法评估能量代谢。在实验过程中，采集血液并分析血浆葡萄糖等生化参数。
在 d-阿洛酮糖组中，脂肪氧化的曲线下面积明显高于对照组（10.5±0.4 与 9.6±0.3kJ·4h·kg 体重；P<0.05），而碳水化合物氧化的曲线下面积明显低于对照组（8.1±0.5 与 9.2±0.5kJ·4h·kg 体重；P<0.05）。此外，d-阿洛酮糖组的血浆葡萄糖水平明显较低，游离脂肪酸水平明显较高。其他参数如胰岛素、总胆固醇或三酰甘油均无改变。
d-阿洛酮糖可增强健康人群的餐后脂肪氧化，表明它可能是一种新型甜味剂，可通过增强能量代谢来控制和维持健康体重。
