Department of Oral and Maxillofacial Surgery (Head: Prof. Dr. Dr. Henning Schliephake), Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany.
Department of Oral and Maxillofacial Surgery (Head: Prof. Dr. Dr. Henning Schliephake), Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany.
J Craniomaxillofac Surg. 2017 Nov;45(11):1784-1787. doi: 10.1016/j.jcms.2017.08.004. Epub 2017 Aug 10.
Adenoid cystic carcinomas are rare malignant tumors of the salivary glands. They are characterized by a high rate of local recurrence, late distant metastasis and a poor disease-free survival. In this study, we analyzed a series of 61 patients who were all treated at the University of Göttingen over a period of 21.0 years.
In all 61 patients with salivary adenoid cystic carcinoma, clinical data, demographic data, risk factors, tumor location, tumor stage, status of surgical margin, surgical treatment, postoperative radiotherapy and follow-up interval were assessed.
The overall survival (OS) and the disease-free survival (DFS) of patients who underwent surgery and those who underwent combined surgery with radiotherapy showed no significant differences. Neither did the T-stage (T1/T2 vs. T3/T4) show significant differences in OS and DFS. Only the status of the surgical margin was significantly associated with a longer OS and a longer DFS.
The present results confirm that the radical surgical resection with clear tumor-free margins is the most important predictor for a longer survival. Adjuvant radiotherapy should be discussed from case to case, but should not be seen as an absolute prognostic factor for OS.
腺样囊性癌是一种罕见的唾液腺恶性肿瘤。其特点是局部复发率高、远处转移晚、无疾病生存率低。本研究分析了在哥廷根大学治疗的 61 例患者，治疗时间为 21.0 年。
对所有 61 例涎腺腺样囊性癌患者的临床资料、人口统计学资料、危险因素、肿瘤部位、肿瘤分期、手术切缘状态、手术治疗、术后放疗及随访间隔进行评估。
手术治疗和联合手术加放疗的患者的总生存率（OS）和无病生存率（DFS）无显著差异。T 分期（T1/T2 与 T3/T4）在 OS 和 DFS 方面也无显著差异。只有手术切缘状态与较长的 OS 和 DFS 显著相关。
目前的结果证实，根治性手术切除并获得无肿瘤的切缘是生存时间延长的最重要预测因素。辅助放疗应根据具体情况讨论，但不应将其视为 OS 的绝对预后因素。
