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益生菌可减少 2 型糖尿病患者细菌易位:一项随机对照研究。

Probiotic reduces bacterial translocation in type 2 diabetes mellitus: A randomised controlled study.

机构信息

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, 113-8421, Japan.

Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, Tokyo, 113-8421, Japan.

出版信息

Sci Rep. 2017 Sep 21;7(1):12115. doi: 10.1038/s41598-017-12535-9.

Abstract

Gut bacterial translocation to the blood may play an important role in the development of insulin resistance in type 2 diabetes. Here, we performed an interventional randomised control study to investigate whether probiotics could reduce bacterial translocation and cause changes in the gut microbiota. Seventy Japanese patients with type 2 diabetes were randomised to two groups: the probiotic group drank Lactobacillus casei strain Shirota-fermented milk, while the control group ingested no probiotics. The trial was conducted for 16 weeks. At baseline, 8 and 16 weeks, the gut microbiota composition in feces and blood, fecal organic acids, and other biochemical parameters were measured. At the end of the study, the fecal counts of the Clostridium coccoides group and Clostridium leptum subgroup in the probiotic group were significantly higher than in the control group. As expected, the fecal counts of total Lactobacillus were significantly higher in the probiotic group. Intriguingly, the total count of blood bacteria was significantly lower in the probiotic group. However, fecal organic acids were comparable between the two groups. Our results showed that probiotic administration reduced bacterial translocation and altered the gut microbiota in Japanese patients with type 2 diabetes mellitus.

摘要

肠道细菌易位进入血液可能在 2 型糖尿病胰岛素抵抗的发展中起重要作用。在这里,我们进行了一项干预性随机对照研究,以调查益生菌是否可以减少细菌易位并引起肠道微生物群的变化。70 名日本 2 型糖尿病患者被随机分为两组:益生菌组饮用干酪乳杆菌 Shirota 发酵乳,而对照组不摄入益生菌。试验进行了 16 周。在基线、8 周和 16 周时,测量粪便和血液中的肠道微生物组成、粪便有机酸和其他生化参数。研究结束时,益生菌组的梭状芽胞杆菌属 coccoides 组和 Clostridium leptum 亚组的粪便计数明显高于对照组。正如预期的那样,益生菌组的总乳酸菌粪便计数明显更高。有趣的是,益生菌组的血液细菌总数明显较低。然而,两组粪便有机酸无差异。我们的结果表明,益生菌的使用减少了 2 型糖尿病日本患者的细菌易位并改变了肠道微生物群。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858d/5608749/7ae4887d8ba1/41598_2017_12535_Fig1_HTML.jpg

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