National Research Institute for Family Planning, Beijing, China.
Graduate School of Peking Union Medical College, Beijing, China.
Sci Rep. 2017 Sep 21;7(1):12090. doi: 10.1038/s41598-017-12005-2.
Globally, one third of prevalent chronic hepatitis B (CHB) virus infection (HBV) occurred in China. Assessing the prevalence of CHB infesction and status of HBV-related services among pre-conception women will provide insight into risks of mother to child transmission (MTCT). A cross-sectional analysis of data from the National Free Pre-pregnancy Checkups (NFPC) program in 2010-2014 was conducted. A standardized questionnaire which collected demographic information and enzyme-linked immunosorbent assays (ELISA) which tested serological HBV markers were applied. A total of 16,051,850 rural women aged 15-49 years were included. 5.2% of women were infected with CHB, among whom, 28.6% were also hepatitis B e antigen (HBeAg) positive. The most CHB concentrated places were distributed in southeastern coastal provinces. Women born after 1992 did not experience a higher level of vaccine-induced immunity compared to those born before 1992. Nine in ten rural women with CHB were not aware of their HBV status and a very small proportion of women (0.22%) had received antiviral treatment. Our data demonstrated an overall high-intermediate burden of CHB. Heterogeneity of geographic distribution, high proportion of HBeAg, insufficient awareness of HBV status, and low access to HBV treatment are challenges for preventing the MTCT.
全球三分之一的慢性乙型肝炎病毒（HBV）感染流行病例发生在中国。评估孕前妇女慢性乙型肝炎感染的流行情况和 HBV 相关服务状况，有助于了解母婴传播（MTCT）的风险。对 2010-2014 年全国免费孕前优生健康检查（NFPC）项目的数据进行了横断面分析。采用标准化问卷收集人口统计学信息，酶联免疫吸附试验（ELISA）检测血清 HBV 标志物。共纳入 16051850 名 15-49 岁农村妇女。5.2%的妇女感染了 CHB，其中 28.6%的妇女 HBeAg 也呈阳性。HBV 最集中的地方分布在东南沿海省份。1992 年后出生的妇女与 1992 年前出生的妇女相比，疫苗诱导的免疫水平并没有更高。十分之九的 CHB 农村妇女不知道自己的 HBV 状况，只有极少数妇女（0.22%）接受过抗病毒治疗。我们的数据显示，CHB 总体负担处于中高度。地理分布的异质性、HBeAg 比例高、HBV 感染状况知晓率低、HBV 治疗可及性低，这些都是预防 MTCT 的挑战。
