Lang Simon B, Cartwright Kaitie C, Welter Richard S, Locascio Theresa M, Tunge Jon A
Department of Chemistry, The University of Kansas, 2010 Malott Hall, 1251 Wescoe Hall Drive, Lawrence KS 66045, (USA).
European J Org Chem. 2016 Jul;2016(20):3331-3334. doi: 10.1002/ejoc.201600620. Epub 2016 Jun 19.
Aminodecarboxylation of unactivated alkyl carboxylic acids has been accomplished utilizing an organic photocatalyst. This operationally simple reaction utilizes readily available carboxylic acids to chemoselectively generate reactive alkyl intermediates that are not accessible via conventional two-electron pathways. The organic radical intermediates are efficiently trapped with electrophilic diazo compounds to provide aminated alkanes.
利用有机光催化剂实现了未活化烷基羧酸的氨基脱羧反应。这个操作简单的反应利用容易获得的羧酸化学选择性地生成通过传统双电子途径无法得到的活性烷基中间体。有机自由基中间体能被亲电重氮化合物有效捕获,从而得到胺化烷烃。