受阻α-氨基羰基的合成：铜催化的与亚硝基化合物的自由基加成反应。
Synthesis of Hindered α-Amino Carbonyls: Copper-Catalyzed Radical Addition with Nitroso Compounds.
机构信息
Department of Chemistry & Biochemistry, University of California , Santa Barbara, California 93106, United States.
出版信息
J Am Chem Soc. 2015 Sep 16;137(36):11614-7. doi: 10.1021/jacs.5b07860. Epub 2015 Sep 2.
PMID:26317926
Abstract
The synthesis of sterically hindered anilines has been a significant challenge in organic chemistry. Here we report a Cu-catalyzed radical addition with in situ-generated nitroso compounds to prepare sterically hindered amines directly from readily available materials. The transformation is conducted at room temperature, uses abundant copper salts, and is tolerant of a range of functional groups.
摘要
位阻苯胺的合成一直是有机化学中的一个重大挑战。在这里，我们报告了一种铜催化的自由基加成反应，通过原位生成的亚硝基化合物直接从易得的原料制备位阻胺。该转化在室温下进行，使用丰富的铜盐，并能容忍一系列官能团。
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