McKelvey Kelly J, Powell Katie L, Ashton Anthony W, Morris Jonathan M, McCracken Sharon A
Division of Perinatal Medicine, Kolling Institute of Medical Research, University of Sydney at Royal North Shore Hospital, St Leonards, NSW, Australia.
Pathology North, NSW Health Pathology at Royal North Shore Hospital, St Leonards, NSW, Australia.
J Circ Biomark. 2015 Jul 17;4:7. doi: 10.5772/61186. eCollection 2015 Jan-Dec.
Exosomes are 30-100 nm microvesicles which contain complex cellular signals of RNA, protein and lipids. Because of this, exosomes are implicated as having limitless therapeutic potential for the treatment of cancer, pregnancy complications, infections, and autoimmune diseases. To date we know a considerable amount about exosome biogenesis and secretion, but there is a paucity of data regarding the uptake of exosomes by immune and non-immune cell types (e.g., cancer cells) and the internal signalling pathways by which these exosomes elicit a cellular response. Answering these questions is of paramount importance.
外泌体是30-100纳米的微泡，其中包含RNA、蛋白质和脂质等复杂的细胞信号。正因如此，外泌体被认为在治疗癌症、妊娠并发症、感染和自身免疫性疾病方面具有无限的治疗潜力。迄今为止，我们对外泌体的生物发生和分泌已经有了相当多的了解，但关于免疫细胞和非免疫细胞类型（如癌细胞）对外泌体的摄取以及这些外泌体引发细胞反应的内部信号通路的数据却很少。回答这些问题至关重要。
