Keller Sascha, Sanderson Michael P, Stoeck Alexander, Altevogt Peter
German Cancer Research Center (DKFZ), Tumor Immunology Program, D010/TP3, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
Immunol Lett. 2006 Nov 15;107(2):102-8. doi: 10.1016/j.imlet.2006.09.005. Epub 2006 Oct 17.
Exosomes are small microvesicles that are released from late endosomal compartments of cultured cells. Recent work has shown that exosome-like vesicles are also found in many body fluids such as blood, urine, ascites and amnionic fluid. Although the biological function of exosomes is far from being fully understood, exosomes may have general importance in cell biology and immunology. The present review aims to address some of the facets of exosome research with particular emphasis on the immunologist's perspective: (i) exosomes as a novel platform for the ectodomain shedding of membrane proteins by ADAMs and (ii) recent findings on the role of exosomes in tumor biology and immune regulation.
外泌体是从培养细胞的晚期内体区室释放的小微泡。最近的研究表明，在许多体液如血液、尿液、腹水和羊水中也发现了类似外泌体的囊泡。尽管外泌体的生物学功能尚未完全了解，但外泌体可能在细胞生物学和免疫学中具有普遍重要性。本综述旨在探讨外泌体研究的一些方面，特别强调免疫学家的观点：（i）外泌体作为ADAMs介导膜蛋白胞外域脱落的新平台，以及（ii）外泌体在肿瘤生物学和免疫调节中作用的最新发现。
