Kumar Saurabh, Tandon Shobha, Nayak Rashmi, Saran Runki, Pentapati Kalyana-Chakravarthy
Department of Pedodontics and Preventive Dentistry, Manipal College of Dental Sciences, Manipal University, Manipal.
Centre of Studies for Paediatric Dentistry and Orthodontics, Faculty of Dentistry, University Technology MARA, Malaysia.
J Clin Exp Dent. 2017 Aug 1;9(8):e958-e961. doi: 10.4317/jced.53796. eCollection 2017 Aug.
Dental caries is a chronic disease among children and there is need for studies assessing the caries risk factors using saliva. This study aimed to evaluate the association of salivary soluble CD14 and dental caries in young children.
A cross-sectional study was done among 300, 3-6 year old school children of Udupi district. A total of 40 children who were caries free, with no past systemic illness or craniofacial anomalies and 40 children with dental caries with no history of dental treatment for caries, with no past systemic illness or craniofacial anomalies were included in control and test groups respectively. Salivary CD14 was evaluated using ELISA test.
The mean salivary soluble CD14 concentration was significantly higher in caries free (1.34±0.35 µg/ml) children than caries experienced (0.54±0.36 µg/ml) (<0.001). There was significant strong negative correlation between number of decayed teeth and soluble salivary CD14 (r = -0.868, < 0.001) among all the children. Similarly, sub-group analysis of caries experienced children also showed significant strong negative correlation between number of decayed teeth and soluble salivary CD14 (r = -0.774, <0.001).
Results obtained in our study suggested that salivary CD14 can be a indicator of dental caries in young children. Caries, CD14, Children, Saliva.
龋齿是儿童中的一种慢性疾病，需要开展研究以评估使用唾液检测龋齿风险因素的情况。本研究旨在评估幼儿唾液可溶性CD14与龋齿之间的关联。
在乌杜皮地区对300名3至6岁的学童开展了一项横断面研究。对照组和试验组分别纳入了40名无龋齿、无既往全身性疾病或颅面畸形的儿童，以及40名有龋齿但无龋齿治疗史、无既往全身性疾病或颅面畸形的儿童。使用酶联免疫吸附测定（ELISA）试验评估唾液CD14。
无龋齿儿童（1.34±0.35微克/毫升）的唾液可溶性CD14平均浓度显著高于有龋齿儿童（0.54±0.36微克/毫升）（<0.001）。在所有儿童中，龋齿数与唾液可溶性CD14之间存在显著的强负相关（r = -0.868，<0.001）。同样，对有龋齿儿童的亚组分析也显示，龋齿数与唾液可溶性CD14之间存在显著的强负相关（r = -0.774，<0.001）。
我们的研究结果表明，唾液CD14可能是幼儿龋齿的一个指标。龋齿、CD14、儿童、唾液。
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