电休克治疗中的研究行为是否符合伦理？
Is Conduct of Research in Electroconvulsive Therapy Ethical?
作者信息
Youssef N A, McCall W V
机构信息
Department of Psychiatry & Health Behavior, The Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
出版信息
J Psychol Neuropsychiatr Disord Brain Stimul. 2016;1(1). doi: 10.19104/jpbd.2016.105. Epub 2016 May 13.
INTRODUCTION
Controversy surrounding ECT creates skepticism about the ethics of conducting ECT research. This paper discusses the ethical conduct of clinical research and then focus on the ethics as applied to ECT.
METHODS
PubMed was searched for articles related to the ethical conduct of research and that of ECT research published in English.
RESULTS
ECT research is ethically justified and should always continue to be conducted with the highest ethical standards. ECT research entails few ethical peculiarities such as involving multiple sessions were capacity to consent can change. It would be unethical not to conduct ECT research.
CONCLUSION
ECT research must be based on sound hypotheses in the presence of a clinical equipoise in well-designed studies. ECT studies must select a fair and non-biased sample of participants. It is important that participants represent the broad population of the people that would be receiving ECT for that specific indication. ECT research is ethical; and more research in this field could help decrease stigma and barriers to treatment, and/or reduce side effects and improve efficacy of a potentially life-saving intervention.
引言
围绕电休克治疗（ECT）的争议引发了对开展ECT研究伦理问题的怀疑。本文讨论了临床研究的伦理行为，然后着重探讨应用于ECT的伦理问题。
方法
在PubMed上搜索以英文发表的与研究伦理行为及ECT研究伦理行为相关的文章。
结果
ECT研究在伦理上是合理的，并且应该始终以最高的伦理标准继续进行。ECT研究存在一些伦理特殊性，例如涉及多个疗程，在此期间同意能力可能会发生变化。不开展ECT研究将是不道德的。
结论
ECT研究必须基于合理的假设，且存在临床 equipoise，同时要有精心设计的研究。ECT研究必须选择公平且无偏见的参与者样本。重要的是，参与者要代表因该特定适应症而接受ECT治疗的广大人群。ECT研究是符合伦理的；该领域更多的研究有助于减少污名化和治疗障碍，和/或减少副作用并提高一种可能挽救生命的干预措施的疗效。
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