外泌体的心脏保护作用及其潜在治疗用途。

Cardioprotective Effects of Exosomes and Their Potential Therapeutic Use.

作者信息

Ding Shengguang, Zhang Jingying, Dai Qiying, Zhao Mengfei, Huang Haitao, Xu Yiming, Zhong Chongjun

机构信息

Department of Thoracic and Cardiovascular Surgery, The Second Affiliated Hospital of Nantong University, Nantong, 226001, China.

Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.

出版信息

Adv Exp Med Biol. 2017;998:163-177. doi: 10.1007/978-981-10-4397-0_11.

DOI:10.1007/978-981-10-4397-0_11

PMID:28936739

Abstract

Exosomes are membrane-contained vesicles released by various types of cells both in animals and human. They contain microRNAs and proteins and can travel to target cells, affecting their functions. There are specific factors on the surface of every exosomes, making sure that they will be taken up by certain type of cells. With these features, exosomes have been recognized to be one of the fundamental "messengers" for cell-cell communication. Recently, increased interest has been raised in exosomes since they were discovered to play an unneglectable role in preserving cardiac function and cardiomyocyte repair during stress. The widely explored stem cell therapy for cardiomyopathy uncovered the contribution of exosomes. Here we summarized cardioprotective effects of exosomes and their potential therapeutic use.

摘要

外泌体是动物和人类各种类型细胞释放的膜包囊泡。它们含有微小RNA和蛋白质，能够到达靶细胞并影响其功能。每个外泌体表面都有特定因子，确保它们能被特定类型的细胞摄取。凭借这些特性，外泌体已被公认为细胞间通讯的基本“信使”之一。最近，自发现外泌体在应激期间保护心脏功能和心肌细胞修复中发挥不可忽视的作用以来，人们对其兴趣日益增加。广泛探索的心肌病干细胞疗法揭示了外泌体的作用。在此，我们总结了外泌体的心脏保护作用及其潜在的治疗用途。