外泌体：无细胞心血管疾病治疗的未来展望。

Exosomes: Outlook for Future Cell-Free Cardiovascular Disease Therapy.

作者信息

Barani Bahar, Rajasingh Sheeja, Rajasingh Johnson

机构信息

Division of Cardiovascular Diseases, Department of Internal Medicine, Cardiovascular Research Institute, University of Kansas Medical Center, Kansas City, KS, USA.

Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS, 66160, USA.

出版信息

Adv Exp Med Biol. 2017;998:285-307. doi: 10.1007/978-981-10-4397-0_19.

DOI:10.1007/978-981-10-4397-0_19

PMID:28936747

Abstract

Cardiovascular diseases are the number one cause of death globally with an estimated 7.4 million people dying from coronary heart disease. Studies have been conducted to identify the therapeutic utility of exosomes in many diseases, including cardiovascular diseases. It has been demonstrated that exosomes are immune modulators, can be used to treat cardiac ischemic injury, pulmonary hypertension and many other diseases, including cancers. Exosomes can be used as a biomarker for disease and cell-free drug delivery system for targeting the cells. Many studies suggest that exosomes can be used as a cell-free vaccine for many diseases. In this chapter, we explore the possibility of future therapeutic potential of exosomes in various cardiovascular diseases.

摘要

心血管疾病是全球头号死因，估计有740万人死于冠心病。人们已经开展了多项研究来确定外泌体在包括心血管疾病在内的多种疾病中的治疗效用。已经证明，外泌体是免疫调节剂，可用于治疗心脏缺血性损伤、肺动脉高压以及包括癌症在内的许多其他疾病。外泌体可用作疾病的生物标志物和靶向细胞的无细胞药物递送系统。许多研究表明，外泌体可作为多种疾病的无细胞疫苗。在本章中，我们探讨了外泌体在各种心血管疾病中未来治疗潜力的可能性。