Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China.
Department of Ultrasound Diagnosis, Tibet Second People's Hospital, Lhasa, Tibet 850000, China.
Chin Med J (Engl). 2017 Oct 5;130(19):2316-2320. doi: 10.4103/0366-6999.215327.
Lhasa is the main residence of Tibetans and one of the highest cities in the world. Its unique geography and ethnic population provide the chance to investigate the interactions among high altitude, ethnicity, and cardiac adaptation. Meanwhile, echocardiographic data about healthy Tibetans on a large scale are not available. This study aimed to analyze physiological factors related to ventricular size and valvular function in healthy Tibetans in Lhasa.
A representative sample of residents in Tibet was recruited using a multistage cluster random sampling method. Two-dimensional echocardiographic measurements and Doppler evaluation for valvular function were performed. Healthy Tibetans in Lhasa constituted the study population. Associations between physiological parameters and ventricular dimensions in healthy Tibetans were analyzed by canonical correlation analysis. Factors related to valvular regurgitations were determined by logistic regression analysis.
The 454 healthy Tibetans (340 females and 114 male) in Lhasa were included in the final analysis. Canonical correlation analysis revealed that weight was positively correlated with the proximal right ventricular outflow diameter and the basal left ventricular linear dimension in both genders. Weight and pulse were negatively related to mild tricuspid regurgitation. Age was a positive factor for pulmonary and aortic regurgitations. The same was found between systolic blood pressure and mitral regurgitation.
Weight is associated with ventricular size and valvular regurgitation in healthy Tibetans. It should be of more concern in research of high altitude population.
拉萨是藏族人的主要居住地，也是世界上海拔最高的城市之一。其独特的地理和民族人口为研究高海拔、民族和心脏适应之间的相互作用提供了机会。同时，拉萨健康藏族人的大规模超声心动图数据尚不可用。本研究旨在分析拉萨健康藏族人心室大小和瓣膜功能相关的生理因素。
采用多阶段聚类随机抽样方法，对西藏居民进行了代表性抽样。进行二维超声心动图测量和瓣膜功能多普勒评估。将拉萨的健康藏族人作为研究人群。通过典型相关分析，分析健康藏族人心室尺寸与生理参数之间的关系。通过逻辑回归分析确定与瓣膜反流相关的因素。
最终纳入了 454 名健康的拉萨藏族人（340 名女性和 114 名男性）进行了最终分析。典型相关分析显示，体重与男女的右室流出道近端直径和左室基底部线性维度呈正相关。体重和脉搏与轻度三尖瓣反流呈负相关。年龄是肺动脉瓣和主动脉瓣反流的正相关因素。收缩压与二尖瓣反流之间也存在同样的关系。
体重与健康藏族人心室大小和瓣膜反流有关。在高海拔人群的研究中应更加关注。
