Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, China.
Department of Cardiovascular Ultrasound and Noninvasive Cardiology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China.
J Am Soc Echocardiogr. 2015 May;28(5):570-9. doi: 10.1016/j.echo.2015.01.022. Epub 2015 Mar 7.
Currently available echocardiographic reference values are derived mainly from North American and European population studies, and no echocardiographic reference values are available for the Chinese population. The aim of this study was to establish normal values of echocardiographic measurements of the cardiac chambers and great arteries in a nationwide, population-based cohort of healthy Han Chinese adults.
A total of 1,586 healthy Han Chinese volunteers aged 18 to 79 years were screened at 43 collaborating laboratories throughout China. Standard M-mode and two-dimensional echocardiography was performed to obtain measurements of the cardiac chambers and great arteries. The impacts of gender and age on all echocardiographic measurements were analyzed.
A total of 1,394 qualified healthy subjects (mean age, 47.3 ± 16.0 years; 678 men) were ultimately enrolled. Except for left ventricular ejection fraction, values of cardiac chamber and great arterial dimensions were significantly higher in men than in women. Most measurements of the atrial and great arterial dimensions, left ventricular wall thickness, and left ventricular mass increased with age in both men and women.
Normal reference values of cardiac dimensional parameters were established for the first time in a nationwide, population-based cohort of healthy Han Chinese adults. Because most of these parameters were found to vary with gender and age, reference values stratified for gender and age should be used in clinical practice.
目前可用的超声心动图参考值主要来源于北美和欧洲人群研究，而中国人群的超声心动图参考值尚不清楚。本研究旨在建立中国汉族健康成年人全国性、基于人群的超声心动图心脏腔室和大血管测量的正常值。
在中国 43 个合作实验室共筛选了 1586 名年龄在 18 至 79 岁的健康汉族志愿者。标准 M 型和二维超声心动图用于获取心脏腔室和大血管的测量值。分析了性别和年龄对所有超声心动图测量值的影响。
最终共纳入 1394 名合格的健康受试者（平均年龄为 47.3±16.0 岁；678 名男性）。除左心室射血分数外，男性的心脏腔室和大血管尺寸值均显著高于女性。男女的心房和大血管尺寸、左心室壁厚度和左心室质量的大部分测量值均随年龄增长而增加。
首次在全国性、基于人群的汉族健康成年人队列中建立了心脏维度参数的正常参考值。由于这些参数中的大多数与性别和年龄有关，因此在临床实践中应使用按性别和年龄分层的参考值。
