• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Immunoreduction of ocular surface tumours with intralesional interferon alpha-2a.局部注射干扰素 alpha-2a 减少眼表面肿瘤的免疫反应。
Eye (Lond). 2018 Feb;32(2):460-462. doi: 10.1038/eye.2017.196. Epub 2017 Sep 22.
2
Giant ocular surface squamous neoplasia managed with interferon alpha-2b as immunotherapy or immunoreduction.巨大多形性眼表鳞状细胞肿瘤采用干扰素 α-2b 进行免疫治疗或免疫抑制治疗。
Ophthalmology. 2012 May;119(5):938-44. doi: 10.1016/j.ophtha.2011.11.035. Epub 2012 Feb 22.
3
Recombinant interferon alpha 2b for ocular surface squamous neoplasia: An efficient and cost-effective treatment modality in Asian Indian patients.重组干扰素α-2b治疗眼表鳞状上皮肿瘤：亚洲印度患者的一种有效且具有成本效益的治疗方式。
Indian J Ophthalmol. 2016 Oct;64(10):702-709. doi: 10.4103/0301-4738.195010.
4
Intralesional interferon-α for conjunctival mucosa-associated lymphoid tissue lymphoma: long-term results.结膜黏膜相关淋巴组织淋巴瘤的病灶内干扰素-α治疗：长期结果。
Ophthalmology. 2012 Mar;119(3):494-500. doi: 10.1016/j.ophtha.2011.09.008. Epub 2012 Jan 5.
5
Interferon alpha-2b in giant ocular surface squamous neoplasia.干扰素α-2b治疗巨大眼表鳞状细胞癌
Indian J Ophthalmol. 2016 May;64(5):393-4. doi: 10.4103/0301-4738.185620.
6
Topical interferon or surgical excision for the management of primary ocular surface squamous neoplasia.局部应用干扰素或手术切除治疗原发性眼表鳞状上皮肿瘤
Ophthalmology. 2008 Aug;115(8):1297-302, 1302.e1. doi: 10.1016/j.ophtha.2008.01.006. Epub 2008 Feb 21.
7
Study of efficacy and safety of reconstituted, recombinant human interferon alpha 2b eyedrops without refrigeration as a therapy for immunoreduction and/or treatment of ocular surface squamous neoplasia.重组人干扰素α2b滴眼液无需冷藏复溶后的疗效与安全性研究，用于免疫抑制和/或治疗眼表鳞状细胞癌。
Indian J Ophthalmol. 2021 Dec;69(12):3776-3777. doi: 10.4103/ijo.IJO_885_21.
8
Ocular surface squamous neoplasia treated with topical interferon α 2b.局部应用干扰素α 2b治疗眼表鳞状上皮肿瘤。
BMJ Case Rep. 2017 Jan 18;2017:bcr2016218344. doi: 10.1136/bcr-2016-218344.
9
Pegylated Interferon Alpha 2a for the Treatment of Ocular Surface Squamous Neoplasia.聚乙二醇干扰素α-2a 治疗眼表面鳞状上皮肿瘤。
Cornea. 2022 Oct 1;41(10):1271-1275. doi: 10.1097/ICO.0000000000003086. Epub 2022 Jul 4.
10
Mitomycin C or interferon as adjuvant therapy to surgery for ocular surface squamous neoplasia: comparative study.丝裂霉素C或干扰素作为眼表鳞状上皮肿瘤手术辅助治疗的比较研究。
Eur J Ophthalmol. 2018 Mar;28(2):204-209. doi: 10.5301/ejo.5001035. Epub 2017 Nov 9.

引用本文的文献

1
Conjunctival melanoma: comprehensive insights into clinical features, genetic alterations, and modern treatment approaches.结膜黑色素瘤：对临床特征、基因改变及现代治疗方法的全面见解
Pathol Oncol Res. 2025 Aug 4;31:1612085. doi: 10.3389/pore.2025.1612085. eCollection 2025.
2
Use of Mitomycin C in Ophthalmic Surgery.丝裂霉素C在眼科手术中的应用。
J Curr Ophthalmol. 2025 Jun 5;36(3):211-222. doi: 10.4103/joco.joco_283_23. eCollection 2024 Jul-Sep.
3
Update in the Diagnosis and Management of Ocular Surface Squamous Neoplasia (OSSN).眼表鳞状上皮肿瘤（OSSN）诊断与管理的最新进展
J Clin Med. 2025 Mar 3;14(5):1699. doi: 10.3390/jcm14051699.
4
The Management of Ocular Surface Squamous Neoplasia (OSSN).眼表鳞状细胞肿瘤（OSSN）的处理。
Int J Mol Sci. 2022 Dec 31;24(1):713. doi: 10.3390/ijms24010713.
5
Pegylated interferon-alpha-2a for the treatment of ocular surface squamous neoplasia.聚乙二醇化干扰素α-2a用于治疗眼表鳞状上皮肿瘤。
Oman J Ophthalmol. 2022 Mar 2;15(1):81-84. doi: 10.4103/ojo.ojo_146_21. eCollection 2022 Jan-Apr.
6
Role of interferons in diabetic retinopathy.干扰素在糖尿病视网膜病变中的作用。
World J Diabetes. 2021 Jul 15;12(7):939-953. doi: 10.4239/wjd.v12.i7.939.
7
Ocular surface squamous neoplasia: management and outcomes.眼表鳞状细胞肿瘤：治疗与结局。
Eye (Lond). 2021 Jun;35(6):1562-1573. doi: 10.1038/s41433-021-01422-3. Epub 2021 Feb 9.
8
Current Management of Conjunctival Melanoma Part 2: Treatment and Future Directions.当前结膜黑色素瘤的处理方法 第 2 部分：治疗与未来方向。
Turk J Ophthalmol. 2020 Dec 29;50(6):362-370. doi: 10.4274/tjo.galenos.2020.22567.
9
Resolution of giant ocular surface squamous neoplasia with topical 5-fuorouracil 1.局部应用5-氟尿嘧啶治疗巨大眼表鳞状细胞瘤1例
SAGE Open Med Case Rep. 2019 Apr 17;7:2050313X19843392. doi: 10.1177/2050313X19843392. eCollection 2019.
10
Clinical Management of Ocular Surface Squamous Neoplasia: A Review of the Current Evidence.眼表鳞状上皮肿瘤的临床管理：当前证据综述
Ophthalmol Ther. 2018 Dec;7(2):247-262. doi: 10.1007/s40123-018-0140-z. Epub 2018 Jul 20.

本文引用的文献

1
Topical interferon alfa-2b for management of ocular surface squamous neoplasia in 23 cases: outcomes based on American Joint Committee on Cancer classification.局部应用干扰素α-2b治疗23例眼表鳞状上皮肿瘤：基于美国癌症联合委员会分类的结果
Arch Ophthalmol. 2012 Feb;130(2):159-64. doi: 10.1001/archophthalmol.2011.385.
2
Subconjunctival/perilesional recombinant interferon α2b for ocular surface squamous neoplasia: a 10-year review.结膜下/病变周围重组干扰素 α2b 治疗眼表面鳞状上皮肿瘤：10 年回顾。
Ophthalmology. 2010 Dec;117(12):2241-6. doi: 10.1016/j.ophtha.2010.03.052.
3
Redefining the role of interferon in the treatment of malignant diseases.重新定义干扰素在恶性疾病治疗中的作用。
Eur J Cancer. 2010 Jan;46(2):284-97. doi: 10.1016/j.ejca.2009.10.013. Epub 2009 Nov 10.
4
Incidence of noncutaneous melanomas in the U.S.美国非皮肤黑色素瘤的发病率
Cancer. 2005 Mar 1;103(5):1000-7. doi: 10.1002/cncr.20866.
5
Chemoreduction with topical mitomycin C prior to resection of extensive squamous cell carcinoma of the conjunctiva.在切除广泛的结膜鳞状细胞癌之前，使用局部丝裂霉素C进行化学减灭。
Arch Ophthalmol. 2005 Jan;123(1):109-13. doi: 10.1001/archopht.123.1.109.
6
Metastatic pattern and survival in disseminated conjunctival melanoma: implications for sentinel lymph node biopsy.弥漫性结膜黑色素瘤的转移模式与生存情况：对前哨淋巴结活检的意义
Ophthalmology. 2004 Apr;111(4):816-21. doi: 10.1016/j.ophtha.2003.11.001.
7
Epidemiology of squamous cell conjunctival cancer.结膜鳞状细胞癌的流行病学
Cancer Epidemiol Biomarkers Prev. 1997 Feb;6(2):73-7.
8
Chemoreduction in the initial management of intraocular retinoblastoma.眼内视网膜母细胞瘤初始治疗中的化学减积法
Arch Ophthalmol. 1996 Nov;114(11):1330-8. doi: 10.1001/archopht.1996.01100140530002.
9
The interferons. Mechanisms of action and clinical applications.干扰素。作用机制与临床应用。
JAMA. 1991 Sep 11;266(10):1375-83. doi: 10.1001/jama.266.10.1375.

局部注射干扰素 alpha-2a 减少眼表面肿瘤的免疫反应。

Immunoreduction of ocular surface tumours with intralesional interferon alpha-2a.

机构信息

Sheffield Ocular Oncology Service, Royal Hallamshire Hospital, Sheffield, South Yorkshire S10 2JF, UK.

出版信息

Eye (Lond). 2018 Feb;32(2):460-462. doi: 10.1038/eye.2017.196. Epub 2017 Sep 22.

DOI:10.1038/eye.2017.196
PMID:28937145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5811715/
Abstract

PurposeTo share our initial experience in the use of intralesional interferon alpha-2a at primary presentation in ocular surface tumours as a method of immunoreduction prior to definitive surgical management.MethodsCase series of patients referred to Sheffield Ocular Oncology Service with rapidly growing ocular surface tumours, treated with intralesional interferon alpha-2a at first presentation prior to definitive surgical management.ResultsAll three patients, two with conjunctival melanoma and one with ocular surface squamous neoplasia (OSSN) demonstrated immunoreduction of tumour without any adverse side effects.ConclusionsInterferon alpha-2a is effective in conjunctival melanoma and OSSN. Intralesional interferon at first presentation may be used for immunoreduction prior to definitive surgical management. This may improve surgical and long-term outcomes, improve patient experience, and help meet cancer treatment targets.

摘要

目的

分享我们在眼部表面肿瘤初次就诊时使用病灶内干扰素 α-2a 的初步经验，作为在明确手术治疗前进行免疫还原的方法。

方法

将转诊至谢菲尔德眼部肿瘤专科服务的患有快速生长的眼部表面肿瘤的患者进行病例系列研究，这些患者在接受明确手术治疗前，初次就诊时接受病灶内干扰素 α-2a 治疗。

结果

所有 3 名患者（2 例结膜黑色素瘤和 1 例眼表面鳞状肿瘤）均表现出肿瘤免疫还原，且无任何不良反应。

结论

干扰素 α-2a 对结膜黑色素瘤和眼表面鳞状肿瘤有效。初次就诊时的病灶内干扰素治疗可用于明确手术治疗前的免疫还原。这可能改善手术和长期结果，改善患者体验，并有助于达到癌症治疗目标。