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当前结膜黑色素瘤的处理方法 第 2 部分:治疗与未来方向。

Current Management of Conjunctival Melanoma Part 2: Treatment and Future Directions.

机构信息

Hacettepe University Faculty of Medicine, Department of Ophthalmology, Ocular Oncology Unit, Ankara, Turkey.

出版信息

Turk J Ophthalmol. 2020 Dec 29;50(6):362-370. doi: 10.4274/tjo.galenos.2020.22567.

DOI:10.4274/tjo.galenos.2020.22567
PMID:33389937
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7802095/
Abstract

Conjunctival melanoma is a rare disease which requires tailored management in most cases. The mainstays of treatment can be classified as surgery, topical chemotherapy, radiotherapy, cryotherapy, and other emerging treatment modalities. Herein we review conventional approaches as well as more recently introduced treatment options, together with advances in molecular biology in this particular disease.

摘要

结膜黑色素瘤是一种罕见的疾病,在大多数情况下需要量身定制的治疗方案。治疗的主要方法可以分为手术、局部化疗、放疗、冷冻疗法和其他新兴治疗方法。本文综述了传统方法以及最近引入的治疗选择,以及该疾病中分子生物学的进展。

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Current Management of Conjunctival Melanoma Part 2: Treatment and Future Directions.当前结膜黑色素瘤的处理方法 第 2 部分:治疗与未来方向。
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本文引用的文献

1
Dabrafenib and Trametinib for BRAF-Mutated Conjunctival Melanoma.达拉非尼和曲美替尼用于治疗BRAF突变的结膜黑色素瘤。
Ocul Oncol Pathol. 2020 Jan;6(1):35-38. doi: 10.1159/000497473. Epub 2019 Jul 26.
2
β-Catenin Expression and Activation in Conjunctival Melanoma.β-连环蛋白在结膜黑色素瘤中的表达与激活
Dermatopathology (Basel). 2019 Jun 26;6(2):50-62. doi: 10.1159/000500682. eCollection 2019 Apr-Jun.
3
Management Issues in Conjunctival Tumours: Conjunctival Melanoma and Primary Acquired Melanosis.结膜肿瘤的管理问题:结膜黑色素瘤和原发性获得性黑色素沉着症
Ophthalmol Ther. 2019 Dec;8(4):501-510. doi: 10.1007/s40123-019-00219-8. Epub 2019 Nov 6.
4
Two cases of BRAF-mutated, bulbar conjunctival melanoma, and review of the published literature.两例 BRAF 突变型球结膜黑色素瘤,并复习相关文献。
Clin Exp Dermatol. 2020 Mar;45(2):207-211. doi: 10.1111/ced.14060. Epub 2019 Sep 10.
5
Conjunctival Melanoma Targeted Therapy: MAPK and PI3K/mTOR Pathways Inhibition.结膜黑色素瘤的靶向治疗:MAPK 和 PI3K/mTOR 通路抑制。
Invest Ophthalmol Vis Sci. 2019 Jun 3;60(7):2764-2772. doi: 10.1167/iovs.18-26508.
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Evaluation of interferon alpha 2b as adjunctive therapy for conjunctival melanoma.干扰素α2b作为结膜黑色素瘤辅助治疗的评估。
Am J Ophthalmol Case Rep. 2019 May 22;15:100467. doi: 10.1016/j.ajoc.2019.100467. eCollection 2019 Sep.
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Dabrafenib and Trametinib in BRAF Mutant Metastatic Conjunctival Melanoma.达拉非尼和曲美替尼用于BRAF突变型转移性结膜黑色素瘤的治疗
Front Oncol. 2019 Apr 5;9:232. doi: 10.3389/fonc.2019.00232. eCollection 2019.
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Global microRNA profiling of metastatic conjunctival melanoma.转移性结膜黑色素瘤的全球 miRNA 分析。
Melanoma Res. 2019 Oct;29(5):465-473. doi: 10.1097/CMR.0000000000000606.
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Proton radiotherapy in advanced malignant melanoma of the conjunctiva.结膜晚期恶性黑色素瘤的质子放疗
Graefes Arch Clin Exp Ophthalmol. 2019 Jun;257(6):1309-1318. doi: 10.1007/s00417-019-04286-2. Epub 2019 Mar 27.
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Checkpoint inhibition immunotherapy for advanced local and systemic conjunctival melanoma: a clinical case series.局部晚期和全身转移结膜黑色素瘤的免疫检查点抑制治疗:一项临床病例系列研究。
J Immunother Cancer. 2019 Mar 25;7(1):83. doi: 10.1186/s40425-019-0555-7.