Environmental Health Center, Korea University Anam Hospital.
Department of Pediatrics, College of Medicine, Korea University.
Asian Pac J Allergy Immunol. 2018 Jun;36(2):82-87. doi: 10.12932/AP-100317-0044.
Recent data suggested that imbalance in gut microbiota and gastrointestinal inflammation are associated with the childhood allergic disease. Fecal calprotectin has been used for a non-invasive marker of gut inflammation.
The aim of this study was to investigate the relationships between fecal calprotectin level and the clinical severity of atopic dermatitis (AD) in children.
We enrolled 65 subjects with AD. The concentration of calprotectin was measured in each subject's fecal sample.
The geometric mean fecal calprotectin level of the total subjects was 33.1(10.1-108.9) μg/g. Among the 65 subjects, 44(67.7%) showed calprotectin levels lower than 50μg/g(Group 1), and 21(32.3%) were higher than 50μg/g(Group 2). The mean SCORAD index was significantly higher in Group 2 than Group 1(31.0±16.0 vs 22.2±15.3, p=0.046). The geometric mean serum total IgE levels was higher in Group 2 compared to Group 1(361.4[31.6-992.3]IU/mL vs 175.9[44.3-699.2]IU/mL, p=0.040). The mean blood eosinophils were significantly higher in Group 2 than in Group 1(497.7[239.8-1032.8]/μL vs 281.5[121.5-652.0]/μL, p=0.034). The incidence of exposure to environmental tobacco smoke was significantly higher in Group 2 compared to Group 1(76.2% vs 47.7%, p=0.036). Geometric mean fecal calprotectin level in severe AD was significantly higher than that of mild-to-moderate AD(66.7[13.5-330.3]μg/g vs 29.4[10.1-85.6]μg/g, p=0.044). The fecal calprotectin level significantly correlated with the SCORAD index(r=0.303, p=0.014).
Higher fecal calprotectin levels were observed in subjects with severe AD. Elevated fecal calprotectin level as a gastrointestinal inflammatory marker may associate with childhood AD. Measurement of fecal calprotectin might be useful for assessment of severity of childhood AD.
最近的数据表明，肠道微生物失衡和胃肠道炎症与儿童过敏疾病有关。粪便钙卫蛋白已被用作肠道炎症的非侵入性标志物。
本研究旨在探讨粪便钙卫蛋白水平与儿童特应性皮炎（AD）临床严重程度之间的关系。
我们纳入了 65 名 AD 患儿。测量每位患儿粪便样本中的钙卫蛋白浓度。
总受试者的粪便钙卫蛋白几何均数水平为 33.1(10.1-108.9)μg/g。在 65 名受试者中，44 名（67.7%）的钙卫蛋白水平低于 50μg/g（组 1），21 名（32.3%）高于 50μg/g（组 2）。组 2 的 SCORAD 指数平均值明显高于组 1（31.0±16.0 比 22.2±15.3，p=0.046）。组 2 的血清总 IgE 水平几何均数也高于组 1（361.4[31.6-992.3]IU/mL 比 175.9[44.3-699.2]IU/mL，p=0.040）。组 2 的血嗜酸性粒细胞平均值明显高于组 1（497.7[239.8-1032.8]/μL 比 281.5[121.5-652.0]/μL，p=0.034）。组 2 暴露于环境烟草烟雾的发生率明显高于组 1（76.2%比 47.7%，p=0.036）。重度 AD 的粪便钙卫蛋白水平显著高于轻-中度 AD（66.7[13.5-330.3]μg/g 比 29.4[10.1-85.6]μg/g，p=0.044）。粪便钙卫蛋白水平与 SCORAD 指数显著相关（r=0.303，p=0.014）。
重度 AD 患儿的粪便钙卫蛋白水平较高。升高的粪便钙卫蛋白水平作为一种胃肠道炎症标志物，可能与儿童 AD 有关。测量粪便钙卫蛋白可能有助于评估儿童 AD 的严重程度。
