• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Checks and balances for the iron bank.铁金库的制衡机制。
J Biol Chem. 2017 Sep 22;292(38):15990-15991. doi: 10.1074/jbc.H117.785741.
2
A synergistic role of IRP1 and FBXL5 proteins in coordinating iron metabolism during cell proliferation.IRP1和FBXL5蛋白在细胞增殖过程中协调铁代谢方面的协同作用。
J Biol Chem. 2017 Sep 22;292(38):15976-15989. doi: 10.1074/jbc.M117.785741. Epub 2017 Aug 2.
3
F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis.F-box 和富含亮氨酸重复蛋白 5（FBXL5）是维持细胞和全身铁平衡所必需的。
J Biol Chem. 2013 Jan 4;288(1):552-60. doi: 10.1074/jbc.M112.426171. Epub 2012 Nov 7.
4
Regulation of cellular iron metabolism: Iron-dependent degradation of IRP by SCF ubiquitin ligase.细胞铁代谢的调节：SCF 泛素连接酶介导的 IRP 铁依赖性降解。
Free Radic Biol Med. 2019 Mar;133:64-68. doi: 10.1016/j.freeradbiomed.2018.09.011. Epub 2018 Sep 13.
5
FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster.FBXL5 通过一个氧响应的[2Fe2S]簇调控铁稳态中的 IRP2 稳定性。
Mol Cell. 2020 Apr 2;78(1):31-41.e5. doi: 10.1016/j.molcel.2020.02.011. Epub 2020 Mar 2.
6
Control of iron homeostasis by an iron-regulated ubiquitin ligase.铁稳态的调控由一个铁调节的泛素连接酶来完成。
Science. 2009 Oct 30;326(5953):718-21. doi: 10.1126/science.1176333. Epub 2009 Sep 17.
7
Methods for Studying Iron Regulatory Protein 1: An Important Protein in Human Iron Metabolism.研究铁调节蛋白1的方法：人类铁代谢中的一种重要蛋白质
Methods Enzymol. 2018;599:139-155. doi: 10.1016/bs.mie.2017.09.006. Epub 2017 Dec 6.
8
An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis.一种具有铁反应血红素结构域的 E3 连接酶是铁稳态的调节剂。
Science. 2009 Oct 30;326(5953):722-6. doi: 10.1126/science.1176326. Epub 2009 Sep 17.
9
Influence of sodium nitroprusside on expressions of FBXL5 and IRP2 in SH-SY5Y cells.硝普钠对SH-SY5Y细胞中FBXL5和IRP2表达的影响。
Sheng Li Xue Bao. 2017 Jun 25;69(3):261-266.
10
Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide.铁调节蛋白 1 可与铁调节蛋白 2 竞争，从而调节细胞内铁稳态对一氧化氮的反应。
J Biol Chem. 2011 Jul 1;286(26):22846-54. doi: 10.1074/jbc.M111.231902. Epub 2011 May 12.

引用本文的文献

1
Rational pore engineering reveals the relative contribution of enzymatic sites and self-assembly towards rapid ferroxidase activity and mineralization: impact of electrostatic guiding and cage-confinement in bacterioferritin.合理的孔工程揭示了酶活性位点和自组装对快速铁氧化酶活性和矿化的相对贡献：静电引导和笼状限制在细菌铁蛋白中的作用。
Chem Sci. 2025 Jan 20;16(9):3978-3997. doi: 10.1039/d4sc07021f. eCollection 2025 Feb 26.
2
Inflammation drives alternative first exon usage to regulate immune genes including a novel iron-regulated isoform of .炎症驱动替代的第一外显子使用来调节免疫基因，包括一个新的铁调节的 异构体。
Elife. 2021 May 28;10:e69431. doi: 10.7554/eLife.69431.
3
Arabidopsis BRUTUS-LIKE E3 ligases negatively regulate iron uptake by targeting transcription factor FIT for recycling.拟南芥 BRUTUS-LIKE E3 连接酶通过靶向转录因子 FIT 进行循环来负调控铁的摄取。
Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17584-17591. doi: 10.1073/pnas.1907971116. Epub 2019 Aug 14.
4
Hemerythrin E3 Ubiquitin Ligases as Negative Regulators of Iron Homeostasis in Plants.血红细胞素E3泛素连接酶作为植物铁稳态的负调控因子
Front Plant Sci. 2019 Feb 13;10:98. doi: 10.3389/fpls.2019.00098. eCollection 2019.
5
The Herbert Tabor Young Investigator Awards: Meet the awardees!赫伯特·泰伯青年研究者奖：认识获奖者！
J Biol Chem. 2018 Mar 2;293(9):3468-3469. doi: 10.1074/jbc.E118.002395.

本文引用的文献

1
A synergistic role of IRP1 and FBXL5 proteins in coordinating iron metabolism during cell proliferation.IRP1和FBXL5蛋白在细胞增殖过程中协调铁代谢方面的协同作用。
J Biol Chem. 2017 Sep 22;292(38):15976-15989. doi: 10.1074/jbc.M117.785741. Epub 2017 Aug 2.
2
The role of mitochondria and the CIA machinery in the maturation of cytosolic and nuclear iron-sulfur proteins.线粒体和 CIA 机器在细胞质和核铁硫蛋白成熟中的作用。
Eur J Cell Biol. 2015 Jul-Sep;94(7-9):280-91. doi: 10.1016/j.ejcb.2015.05.002. Epub 2015 May 31.
3
Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.人 CIA2A-FAM96A 和 CIA2B-FAM96B 整合铁稳态和不同细胞溶质-核铁硫蛋白亚群的成熟。
Cell Metab. 2013 Aug 6;18(2):187-98. doi: 10.1016/j.cmet.2013.06.015. Epub 2013 Jul 25.
4
Mammalian iron metabolism and its control by iron regulatory proteins.哺乳动物的铁代谢及其受铁调节蛋白的调控
Biochim Biophys Acta. 2012 Sep;1823(9):1468-83. doi: 10.1016/j.bbamcr.2012.05.010. Epub 2012 May 17.
5
An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis.一种具有铁反应血红素结构域的 E3 连接酶是铁稳态的调节剂。
Science. 2009 Oct 30;326(5953):722-6. doi: 10.1126/science.1176326. Epub 2009 Sep 17.
6
Control of iron homeostasis by an iron-regulated ubiquitin ligase.铁稳态的调控由一个铁调节的泛素连接酶来完成。
Science. 2009 Oct 30;326(5953):718-21. doi: 10.1126/science.1176333. Epub 2009 Sep 17.
7
Structure of dual function iron regulatory protein 1 complexed with ferritin IRE-RNA.与铁蛋白IRE-RNA复合的双功能铁调节蛋白1的结构
Science. 2006 Dec 22;314(5807):1903-8. doi: 10.1126/science.1133116.
8
Reciprocal control of RNA-binding and aconitase activity in the regulation of the iron-responsive element binding protein: role of the iron-sulfur cluster.铁反应元件结合蛋白调控中RNA结合与乌头酸酶活性的相互控制：铁硫簇的作用
Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7536-40. doi: 10.1073/pnas.89.16.7536.

铁金库的制衡机制。

Checks and balances for the iron bank.

作者信息

Outten Caryn E

机构信息

From the Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208

出版信息

J Biol Chem. 2017 Sep 22;292(38):15990-15991. doi: 10.1074/jbc.H117.785741.

DOI:10.1074/jbc.H117.785741
PMID:28939752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5612128/
Abstract

The RNA-binding iron regulatory proteins IRP1 and IRP2 are inactivated by either Fe-S cluster insertion or protein degradation mediated by the E3 ligase component FBXL5. However, the mechanisms for coordination between Fe-S cluster assembly, FBXL5, and IRP1/IRP2 activity are poorly defined. A new study reveals that FBXL5 plays a critical role in limiting IRP1 and IRP2 overaccumulation when cytosolic Fe-S cluster assembly is impaired in order to maintain optimal iron levels for cell viability.

摘要

RNA结合铁调节蛋白IRP1和IRP2可通过铁硫簇插入或由E3连接酶组分FBXL5介导的蛋白质降解而失活。然而，铁硫簇组装、FBXL5和IRP1/IRP2活性之间的协调机制尚不清楚。一项新研究表明，当胞质铁硫簇组装受损时，FBXL5在限制IRP1和IRP2过度积累方面发挥关键作用，以维持细胞存活的最佳铁水平。