Mansoor Muhammad Khalid, Al-Rawahi Abdullmajeed Hamood, El-Tahir Hatim Ali, Al-Faraei Badar, Hussain Muhammad Hammad, Asi Muhammad Nadeem, Al-Hussani Ibrahim, Sabar Safwat
Animal Health Research Center, Ministry of Agriculture & Fisheries, Muscat, Oman.
Veterinary Research Institute, Khartoum, Sudan.
Trop Anim Health Prod. 2018 Jan;50(1):1-3. doi: 10.1007/s11250-017-1391-8. Epub 2017 Sep 22.
Foot and mouth disease (FMD) remains subclinical and self-limiting in small ruminants, but risk of spread of infection to susceptible cohorts is of great epidemiological significance; therefore, small ruminants must be included in vaccination campaigns in FMD endemic regions. Three groups of goats already immunized against peste des petits ruminants (PPR) were vaccinated with FMD and PPR vaccines alone or concurrently. The specific antibody response against three FMD virus strains and PPR virus were evaluated by competitive enzyme-linked immunosorbent assay (cELISA). Goats concurrently vaccinated with PPR + FMD vaccines had significantly (p < 0.05) higher antibody titers to two serotypes of FMD virus at 28, 45, and 60 days post-immunization compared to goats vaccinated with FMD vaccine alone, while goats vaccinated with PPR vaccines alone or PPR + FMD vaccines concurrently showed similar antibody kinetics against PPR virus up till 60 days post-vaccination. Overall, antibody kinetic curves for all three tested strains of FMD virus and PPR virus were similar in vaccinated groups during the course of experiment.
口蹄疫（FMD）在小反刍动物中通常呈亚临床症状且具有自限性，但感染传播至易感群体的风险具有重大的流行病学意义；因此，在口蹄疫流行地区的疫苗接种活动中必须纳入小反刍动物。三组已接种小反刍兽疫（PPR）疫苗的山羊分别单独或同时接种口蹄疫疫苗和PPR疫苗。通过竞争酶联免疫吸附测定（cELISA）评估针对三种口蹄疫病毒株和PPR病毒的特异性抗体反应。与仅接种口蹄疫疫苗的山羊相比，同时接种PPR + 口蹄疫疫苗的山羊在免疫后第28、45和60天对两种口蹄疫病毒血清型的抗体滴度显著更高（p < 0.05），而单独接种PPR疫苗或同时接种PPR + 口蹄疫疫苗的山羊在接种后60天内对PPR病毒的抗体动力学相似。总体而言，在实验过程中，所有三种测试的口蹄疫病毒株和PPR病毒的抗体动力学曲线在接种组中相似。
