使用碲化镉量子点修饰玻碳电极灵敏检测多巴胺的简单策略。
Simple strategy for sensitive detection of dopamine using CdTe QDs modified glassy carbon electrode.
作者信息
Yu Hong-Wei, Zhang Ze, Jiang Jing-Hui, Pan Hong-Zhi, Chang Dong
机构信息
Department of Clinical Laboratory, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Pudong, Shanghai, China.
The First Affiliated Hospital of the Harbin Medical University, Harbin, Heilongjiang Province, China.
出版信息
J Clin Lab Anal. 2018 Mar;32(3). doi: 10.1002/jcla.22320. Epub 2017 Sep 22.
BACKGROUND
Cellular and brain metabolism of dopamine can be correlated with a number of neurodegenerative disorders, our study was to explore a simple and efficient method to detect dopamine in real samples.
METHODS
A new quantum dots (CdTe QDs) could be prepared using the hydrothermal method, the electrochemical biosensor was established by dropping CdTe QDs on the surface of glassy carbon electrode (GCE).
RESULTS
The CdTe QDs/GCE exhibited the excellent electrochemical catalytic activity toward dopamine (DA) with good stability and high sensitivity in presence of interfering substances. The detection limit of DA was calculated by differential pulse voltammetry (DPV) as low as 0.3 μmol L with a linear dynamic range of 1 μmol L to 400 μmol L .
CONCLUSION
In this paper, the proposed electrochemical biosensor could be effectively used for the direct and rapid detection of DA in human serum and urine samples.
背景
多巴胺的细胞和脑代谢与多种神经退行性疾病相关，我们的研究旨在探索一种简单有效的方法来检测实际样本中的多巴胺。
方法
采用水热法制备新型量子点（CdTe量子点），通过将CdTe量子点滴涂在玻碳电极（GCE）表面构建电化学生物传感器。
结果
CdTe量子点修饰玻碳电极（CdTe QDs/GCE）对多巴胺（DA）表现出优异的电化学催化活性，在存在干扰物质的情况下具有良好的稳定性和高灵敏度。通过差分脉冲伏安法（DPV）计算得出DA的检测限低至0.3 μmol/L，线性动态范围为1 μmol/L至400 μmol/L。
结论
本文所提出的电化学生物传感器可有效用于直接快速检测人血清和尿液样本中的DA。
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