Ichimaru Y, Moriyama M, Gomita Y
Life Sci. 1984 Jan 9;34(2):187-92. doi: 10.1016/0024-3205(84)90589-7.
Formation of gastric lesions in response to conditioned emotional stimulus (CES) and effects of benzodiazepines were studied in mice. The CES was introduced in the form of affective communication through a communication box. The "senders" were exposed to electric foot shock and the "responders" were able to receive affective cues such as visual, auditory and olfactory from "senders". The "senders" and "responders" exhibited significantly greater gastric lesions than the controls. Diazepam at doses of 2 X 1 - 2 mg/kg (p.o.) and oxazolam at a dose of 2 X 2 mg/kg (p.o.), reduced the formation of gastric lesions of the "responders" induced non-physically by CES. The present results indicate that "responders" showed bodily changes under CES treatment, particularly in the development of gastric lesions, and that gastric lesions produced by CES were protected by diazepam and oxazolam.
在小鼠中研究了对条件性情绪刺激（CES）的胃损伤形成及苯二氮䓬类药物的作用。CES通过一个通讯箱以情感交流的形式引入。“发送者”暴露于足部电击，“接收者”能够从“发送者”那里接收视觉、听觉和嗅觉等情感线索。“发送者”和“接收者”表现出比对照组明显更多的胃损伤。剂量为2×1 - 2毫克/千克（口服）的地西泮和剂量为2×2毫克/千克（口服）的恶唑仑，减少了CES非物理诱导的“接收者”胃损伤的形成。目前的结果表明，“接收者”在CES处理下出现身体变化，尤其是胃损伤的发展，并且CES产生的胃损伤受到地西泮和恶唑仑的保护。
