Rood J P, Murgatroyd J
Br J Oral Surg. 1979 Jul;17(1):62-70. doi: 10.1016/0007-117x(79)90009-x.
Prophylactic metronidazole was found to be an effective means of preventing 'dry socket' after routine dental extractions. The oral anaerobic bacterial may be implicated therefore in the development of the disorder. It has been confirmed in this study that 'dry socket' occurs following three per cent of routine dental extractions and almost exclusively in the mandible. The causes of the condition are probably numerous and may even vary from patient to patient, but the control of infection by anerobic organisms may be important in its prevention or early resolution. The prophylactic administration of metronidazole (Flagyl) has been shown to be a simple and effective method of prevention which would suggest the implication of anaerobic organisms in 'dry socket'. The drug appears to be free from side effects when a dosage of 200 mgs eight hourly for three days is given.
已发现预防性使用甲硝唑是预防常规拔牙后“干槽症”的有效方法。因此，口腔厌氧菌可能与该病症的发生有关。本研究已证实，“干槽症”发生于3%的常规拔牙后，且几乎仅发生在下颌骨。该病症的病因可能多种多样，甚至可能因患者而异，但控制厌氧菌感染对其预防或早期缓解可能很重要。甲硝唑（灭滴灵）的预防性给药已被证明是一种简单有效的预防方法，这表明厌氧菌与“干槽症”有关。当每八小时服用200毫克，持续三天时，该药似乎没有副作用。
