Reekie D, Downes P, Devlin C V, Nixon G M, Devlin H
Dental School, University of Manchester, Higher Cambridge Street, Manchester M15 6FH.
Br Dent J. 2006 Feb 25;200(4):210-3; discussion 206; quiz 226. doi: 10.1038/sj.bdj.4813253.
The purpose of the study was to determine if the intra-alveolar application of topical metronidazole gel could reduce the incidence of alveolar osteitis (dry socket) following routine tooth extraction in molar and premolar extraction sites.
This was a multicentre, double blind, randomised, placebo-controlled clinical trial. A total of 302 patients took part, of which 23 returned with alveolar osteitis. Of these, eight had received the metronidazole gel and 15 the placebo.
The study was carried out in three general dental practices by general dental practitioners working in England over the period 2000-2003.
Following extraction of either a molar or premolar tooth, either a 25% metronidazole gel or KY Jelly was syringed gently into the socket. A painful post operative complication was recorded if either a dry socket was present or the patient returned with pain.
The difference in the incidence of alveolar osteitis between the placebo and the active gel groups was not significant and it was concluded that 25% topical metronidazole gel was not effective in reducing the incidence of alveolar osteitis. It was found that the incidence of alveolar osteitis reduced with increasing age and was more likely to occur in a patient with a previous history of the condition.
本研究旨在确定在磨牙和前磨牙拔牙部位常规拔牙后，牙槽内应用局部甲硝唑凝胶是否能降低牙槽骨炎（干槽症）的发生率。
这是一项多中心、双盲、随机、安慰剂对照的临床试验。共有302名患者参与，其中23例出现牙槽骨炎。在这些患者中，8例接受了甲硝唑凝胶治疗，15例接受了安慰剂治疗。
该研究于2000年至2003年期间在英国的三名普通牙科医生的三个普通牙科诊所进行。
拔除磨牙或前磨牙后，将25%甲硝唑凝胶或KY胶轻轻注入牙槽窝。如果出现干槽症或患者因疼痛复诊，则记录为术后疼痛并发症。
安慰剂组和活性凝胶组牙槽骨炎发生率的差异无统计学意义，得出结论：25%局部甲硝唑凝胶在降低牙槽骨炎发生率方面无效。研究发现，牙槽骨炎的发生率随年龄增长而降低，且既往有该病史的患者更易发生。
