软体动物神经网络中细胞内环状AMP水平的胺能和肽能放大作用。
Aminergic and peptidergic amplification of intracellular cyclic AMP levels in a molluscan neural network.
作者信息
Yamane T, Gelperin A
机构信息
AT&T bell Laboratories, Murray Hill, New Jersey 07974.
出版信息
Cell Mol Neurobiol. 1987 Sep;7(3):291-301. doi: 10.1007/BF00711305.
Abstract
- Serotonin (5-hydroxytryptamine; 5-HT), dopamine (DA), and small cardioactive peptide B (SCPB) can activate adenylate cyclase and increase the intracellular cyclic AMP (cAMP) levels in the Limax procerebrum (PC), with differing time courses and to differing extents. 5-HT and SCPB are potent stimulators of adenylate cyclase, and when both were applied simultaneously, an additive effect was observed. 2. In contrast, DA shows a great variability in the time course of cAMP synthesis and is a weak stimulator. Ergonovine, a DA antagonist, failed to inhibit cyclase activation, indicating that ergonovine-sensitive receptors are absent or ergonovine-sensitive DA receptors are not coupled to adenylate cyclase. 3. 5-HT and SCPB cause a rapid synthesis of cAMP, reaching the maximum 20- to 30-fold increase within a minute. DA's effect is slow in onset and very prolonged, reaching a maximum of only a two- to three-fold increase in the cAMP level. Reasons for variability in DA action are discussed.
摘要
- 血清素（5-羟色胺；5-HT）、多巴胺（DA）和小的心脏活性肽B（SCPB）可激活蛞蝓大脑前部（PC）中的腺苷酸环化酶，并在不同的时间进程和不同程度上增加细胞内环状AMP（cAMP）水平。5-HT和SCPB是腺苷酸环化酶的强效刺激剂，当两者同时应用时，观察到相加效应。2. 相比之下，DA在cAMP合成的时间进程中表现出很大的变异性，并且是一种弱刺激剂。麦角新碱，一种DA拮抗剂，未能抑制环化酶的激活，表明不存在麦角新碱敏感受体或麦角新碱敏感的DA受体未与腺苷酸环化酶偶联。3. 5-HT和SCPB导致cAMP的快速合成，在一分钟内达到最大增加20至30倍。DA的作用起效缓慢且非常持久，cAMP水平最多仅增加两至三倍。文中讨论了DA作用变异性的原因。
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