Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Clin Mol Hepatol. 2017 Sep;23(3):189-195. doi: 10.3350/cmh.2017.0033. Epub 2017 Sep 19.
Viral hepatitis is one of major global health challenges with increasing disease burden worldwide. Hepatitis B virus and hepatitis C virus infections are major causes of chronic liver diseases. They can lead to cirrhosis, hepatocellular carcinoma, and death in significant portion of affected people. Transmission of hepatitis B virus can be blocked by vaccination. Progression of hepatitis B virus-related liver diseases can be prevented by long-term viral suppression with effective drugs. Although vaccine for hepatitis C virus is currently unavailable, hepatitis C virus infection can be eradicated by oral direct antiviral agents. To eliminate viral hepatitis, World Health Organization (WHO) has urged countries to develop national goals and targets through reducing 90% of new infections and providing universal access to key treatment services up to 80%. This can lead to 65% reduction of viral hepatitis-related mortality. Here, we discuss some key features of viral hepatitis, strategies to control viral hepatitis suggested by WHO, and current status and strategies for viral hepatitis control in South Korea. To achieve the goal of viral hepatitis elimination by 2030 in South Korea, an independent 'viral hepatitis sector' in Centers for Disease Control & Prevention (CDC) needs to be established to organize and execute comprehensive strategy for the management of viral hepatitis in South Korea.
病毒性肝炎是全球主要的健康挑战之一,全球疾病负担不断增加。乙型肝炎病毒和丙型肝炎病毒感染是慢性肝病的主要病因。它们可导致部分感染者发展为肝硬化、肝细胞癌和死亡。乙型肝炎病毒的传播可通过疫苗接种来阻断。通过长期使用有效药物抑制病毒复制,可以预防乙型肝炎病毒相关肝病的进展。虽然目前尚无丙型肝炎病毒疫苗,但口服直接抗病毒药物可消除丙型肝炎病毒感染。为消除病毒性肝炎,世界卫生组织(WHO)敦促各国通过减少 90%的新感染病例,并普及关键治疗服务(达到 80%)来制定国家目标和指标。这可使病毒性肝炎相关死亡率降低 65%。本文讨论了病毒性肝炎的一些关键特征、WHO 提出的控制病毒性肝炎的策略,以及韩国病毒性肝炎控制的现状和策略。为了在 2030 年实现韩国消除病毒性肝炎的目标,需要在疾病预防控制中心(CDC)建立一个独立的“病毒性肝炎部门”,以组织和执行韩国病毒性肝炎管理的综合策略。