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Efficient generation of the mouse model with a defined point mutation through haploid cell-mediated gene editing.

作者信息

Wei Leixin, Wang Xiukun, Yang Suming, Yuan Wen, Li Jinsong

机构信息

Department of Orthopaedic Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China; State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai 200031, China.

State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai 200031, China.

出版信息

J Genet Genomics. 2017 Sep 20;44(9):461-463. doi: 10.1016/j.jgg.2017.07.004. Epub 2017 Aug 12.

DOI:10.1016/j.jgg.2017.07.004
PMID:28943147
Abstract
摘要

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Haploid embryonic stem cells can be enriched and maintained by simple filtration.通过简单的过滤可以富集和维持单倍体胚胎干细胞。
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