Okada Takenori, Takaekou Yuji, Idei Naomi, Ohashi Norihiko, Kaseda Shunichi
Department of Cardiology, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Japan.
Intern Med. 2017 Nov 1;56(21):2891-2894. doi: 10.2169/internalmedicine.8893-17. Epub 2017 Sep 25.
The effect of non-vitamin K antagonist oral anticoagulants on left atrial appendage (LAA) thrombus has not been fully elucidated. There are a few reports showing resolution of LAA thrombus with apixaban. An 84-year-old woman was admitted to our hospital due to acute exacerbation of chronic heart failure and marked tachycardia with atrial fibrillation. She had permanent atrial fibrillation and was treated with warfarin; however, transthoracic echocardiography revealed a non-mobile thrombus in the LAA. Therefore, we switched warfarin to apixaban at a dose of 5 mg/day. After two weeks on that therapy, the thrombus in the LAA was successfully resolved.
非维生素K拮抗剂口服抗凝药对左心耳（LAA）血栓的影响尚未完全阐明。有一些报告显示阿哌沙班可使LAA血栓溶解。一名84岁女性因慢性心力衰竭急性加重和房颤伴显著心动过速入住我院。她患有永久性房颤，一直在接受华法林治疗；然而，经胸超声心动图显示LAA内有一个不活动的血栓。因此，我们将华法林换成了阿哌沙班，剂量为5毫克/天。在该治疗两周后，LAA内的血栓成功溶解。
