Bruneau Michael, Angelopoulos Theodore J, Gordon Paul, Moyna Niall, Visich Paul, Zoeller Robert, Seip Rick, Bilbie Stephen, Thompson Paul, Devaney Joseph, Gordish-Dressman Heather, Hoffman Eric, Pescatello Linda S
Drexel UniversityPhiladelphiaPennsylvania.
Emory & Henry CollegeEmoryVirginia.
Mol Genet Genomic Med. 2017 Jul 2;5(5):524-530. doi: 10.1002/mgg3.308. eCollection 2017 Sep.
The angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism (rs4340) ( accounts for half of the variability in plasma ACE concentrations. has been widely studied for its influence on sports performance; however, research on its influence in physical activity is limited and inconsistent. We examined the influence of the on physical activity among 461 European Americans.
Subjects completed the Paffenbarger Physical Activity Questionnaire for weekly walking distance. Multivariate analysis of covariance (MANCOVA) tested log-transformed differences in weekly walking distance among genotypes (II, ID, DD) with gender as a fixed factor, and age and body mass index (BMI) as covariates. Because we found a significant xBMI interaction ( = 0.03), we categorized the sample by normal weight (NW: BMI<25.0 kg/m) and overweight (OW: BMI ≥25.0 kg/m) and repeated the MANCOVA with multiple comparison adjustments.
NW adults with II walked 15.8 ± 11.1 km/week, ID 13.2 ± 10.6 km/week, and DD 17.9 ± 13.0 km/week, with ID walking less than II ( = 0.03) and DD ( = 0.01). OW adults with II walked 16.7 ± 12.6 km/week, ID 13.8 ± 11.6 km/week, and DD 9.7 ± 9.0 km/week, with DD walking less than II ( = 0.02). Weekly walking distance was 8.2 ± 2.4 km/week less among OW adults with DD than NW ( = 0.02).
BMI interacted with DD such that OW walked ~8.2 km/week less than NW, potentially equating to a body weight differential of ~3.5 kg annually.
血管紧张素转换酶（ACE）插入/缺失（I/D）多态性（rs4340）占血浆ACE浓度变异性的一半。其对运动表现的影响已得到广泛研究；然而，关于其对身体活动影响的研究有限且结果不一致。我们在461名欧裔美国人中研究了该多态性对身体活动的影响。
受试者完成帕芬巴格身体活动问卷以获取每周步行距离。多变量协方差分析（MANCOVA）以性别作为固定因素，年龄和体重指数（BMI）作为协变量，测试不同基因型（II、ID、DD）之间每周步行距离的对数转换差异。由于我们发现了显著的BMI交互作用（P = 0.03），我们将样本按正常体重（NW：BMI<25.0 kg/m²）和超重（OW：BMI≥25.0 kg/m²）进行分类，并在进行多重比较调整后重复MANCOVA。
NW成年人中，携带ACE II基因型者每周步行15.8±11.1千米，ID基因型者每周步行13.2±10.6千米，DD基因型者每周步行17.9±13.0千米，ID基因型者的步行距离少于II基因型者（P = 0.03）和DD基因型者（P = 0.01）。OW成年人中，携带ACE II基因型者每周步行16.7±12.6千米，ID基因型者每周步行13.8±11.6千米，DD基因型者每周步行9.7±9.0千米，DD基因型者的步行距离少于II基因型者（P = 0.02）。携带ACE DD基因型的OW成年人每周步行距离比NW成年人少8.2±2.4千米（P = 0.02）。
BMI与ACE DD基因型存在交互作用，使得OW成年人比NW成年人每周少步行约8.2千米，这可能相当于每年体重相差约3.5千克。
