Thompson Paul D, Tsongalis Gregory J, Ordovas Jose M, Seip Richard L, Bilbie Cherie, Miles Mary, Zoeller Robert, Visich Paul, Gordon Paul, Angelopoulos Theodore J, Pescatello Linda, Moyna Niall
Hartford Hospital, Hartford, CT 06102, USA.
Prev Cardiol. 2006 Winter;9(1):21-4. doi: 10.1111/j.1520-037x.2006.04367.x.
Angiotensin-converting enzyme (ACE) has two common genetic variants: the insertion (I) and deletion (D) forms. ACE levels are greater in subjects with the D allele, and several studies suggest superior endurance performance in subjects with the I allele. The authors recently reported the results of a 6-month exercise training protocol examining the effect of apolipoprotein E on the lipid response. The present report examines the relationship of ACE genotype and exercise adherence. DNA samples were available for 110 subjects: 14 I/I, 52 I/D, and 44 D/D. Baseline and change in maximal oxygen uptake, body mass index, skinfold thickness, and serum lipids did not differ by ACE genotype, but adherence to exercise training was higher in I carriers than in D homozygotes. These preliminary results suggest that ACE genotype affects exercise adherence and raises the possibility that superior endurance capacity in subjects with the I allele is related to a genetic propensity to adhere to an exercise regimen.
血管紧张素转换酶（ACE）有两种常见的基因变体：插入（I）型和缺失（D）型。携带D等位基因的受试者体内ACE水平更高，多项研究表明携带I等位基因的受试者具有更优的耐力表现。作者最近报告了一项为期6个月的运动训练方案的结果，该方案研究了载脂蛋白E对脂质反应的影响。本报告探讨了ACE基因型与运动依从性之间的关系。110名受试者提供了DNA样本：14名I/I型、52名I/D型和44名D/D型。最大摄氧量、体重指数、皮褶厚度和血脂的基线值及变化在不同ACE基因型之间并无差异，但I等位基因携带者的运动训练依从性高于D纯合子。这些初步结果表明，ACE基因型会影响运动依从性，并增加了携带I等位基因的受试者具有更优耐力能力与坚持运动方案的遗传倾向有关的可能性。
