性发育差异（障碍）的儿科患者生育力保存的伦理学
The Ethics of Fertility Preservation for Pediatric Patients With Differences (Disorders) of Sex Development.
作者信息
Campo-Engelstein Lisa, Chen Diane, Baratz Arlene B, Johnson Emilie K, Finlayson Courtney
机构信息
Alden March Bioethics Institute, Department of Obstetrics and Gynecology, Albany Medical College, Albany, New York 12208.
Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois 60611.
出版信息
J Endocr Soc. 2017 Jun 1;1(6):638-645. doi: 10.1210/js.2017-00110.
Abstract
Differences (disorders) of sex development are diverse conditions with variations in chromosomal, gonadal, and/or genital development. Fertility potential in this population is variable. Recent investigations into fertility potential in those previously thought to be infertile suggest that the majority may have fertility potential through experimental protocols. Fertility preservation may be more successful if pursued in childhood. As fertility research and techniques advance, it is important to carefully consider pediatric ethical issues specific to this population, including gonadectomy, consent/assent, experimental treatment and false hope, cost and insurance coverage, genetic transmission to offspring, and gender dysphoria.
摘要
性发育差异是指染色体、性腺和/或生殖器发育存在变异的多种情况。该人群的生育潜力各不相同。最近对那些以前被认为不育者的生育潜力进行的调查表明，通过实验方案，大多数人可能具有生育潜力。如果在儿童期进行生育力保存，可能会更成功。随着生育力研究和技术的进步，仔细考虑该人群特有的儿科伦理问题很重要，包括性腺切除术、同意/赞同、实验性治疗和虚假希望、成本和保险覆盖范围、遗传传递给后代以及性别焦虑症。
相似文献
1
The Ethics of Fertility Preservation for Pediatric Patients With Differences (Disorders) of Sex Development.
J Endocr Soc. 2017 Jun 1;1(6):638-645. doi: 10.1210/js.2017-00110.
2
Fertility Preservation for a Teenager with Differences (Disorders) of Sex Development: An Ethics Case Study.
J Clin Ethics. 2019 Summer;30(2):143-153.
3
The ethics of offering fertility preservation to pediatric patients: A case-based discussion of barriers for clinicians to consider.
Semin Pediatr Surg. 2021 Oct;30(5):151095. doi: 10.1016/j.sempedsurg.2021.151095. Epub 2021 Sep 4.
4
Preservation of Fertility Potential for Gender and Sex Diverse Individuals.
Transgend Health. 2016 Jan 1;1(1):41-44. doi: 10.1089/trgh.2015.0010. eCollection 2016.
5
Fertility Preservation for Pediatric Patients: Current State and Future Possibilities.
J Urol. 2017 Jul;198(1):186-194. doi: 10.1016/j.juro.2016.09.159. Epub 2017 Feb 9.
6
Establishing reproductive potential and advances in fertility preservation techniques for XY individuals with differences in sex development.
Clin Endocrinol (Oxf). 2019 Aug;91(2):237-244. doi: 10.1111/cen.13994. Epub 2019 May 2.
7
Future fertility for individuals with differences of sex development: Parent attitudes and perspectives about decision-making.
J Pediatr Urol. 2017 Aug;13(4):402-413. doi: 10.1016/j.jpurol.2017.06.002. Epub 2017 Jul 3.
8
Presence of Germ Cells in Disorders of Sex Development: Implications for Fertility Potential and Preservation.
J Urol. 2017 Mar;197(3 Pt 2):937-943. doi: 10.1016/j.juro.2016.08.108. Epub 2016 Nov 10.
9
Female fertility preservation in DSD.
Best Pract Res Clin Endocrinol Metab. 2019 Jun;33(3):101289. doi: 10.1016/j.beem.2019.101289. Epub 2019 Jul 9.
10
Fertility in disorders of sex development: A review.
J Pediatr Urol. 2016 Dec;12(6):418-425. doi: 10.1016/j.jpurol.2016.09.015. Epub 2016 Nov 3.
引用本文的文献
1
Fertility Discussions: Perspectives of Adolescents and Young Adults With Differences of Sex Development.
Clin Pract Pediatr Psychol. 2021 Dec;9(4):372-383. doi: 10.1037/cpp0000373. Epub 2020 Dec 3.
2
A View from the past into our collective future: the oncofertility consortium vision statement.
J Assist Reprod Genet. 2021 Jan;38(1):3-15. doi: 10.1007/s10815-020-01983-4. Epub 2021 Jan 6.
3
Engineered reproductive tissues.
Nat Biomed Eng. 2020 Apr;4(4):381-393. doi: 10.1038/s41551-020-0525-x. Epub 2020 Apr 6.
4
Turner Syndrome with Y Chromosome: Spontaneous Thelarche, Menarche, and Risk of Malignancy.
J Pediatr Adolesc Gynecol. 2020 Feb;33(1):10-14. doi: 10.1016/j.jpag.2019.08.011. Epub 2019 Aug 26.
5
A Management Protocol for Gonad Preservation in Patients with Androgen Insensitivity Syndrome.
J Pediatr Adolesc Gynecol. 2019 Dec;32(6):605-611. doi: 10.1016/j.jpag.2019.06.005. Epub 2019 Jun 21.
6
Gonadal Tissue Cryopreservation for a Girl With Partial Androgen Insensitivity Syndrome.
J Endocr Soc. 2019 Mar 13;3(5):887-891. doi: 10.1210/js.2019-00023. eCollection 2019 May 1.
7
The National Physicians Cooperative: transforming fertility management in the cancer setting and beyond.
Future Oncol. 2018 Dec;14(29):3059-3072. doi: 10.2217/fon-2018-0278. Epub 2018 Nov 26.
8
Disorders of sex development.
Best Pract Res Clin Obstet Gynaecol. 2018 Apr;48:90-102. doi: 10.1016/j.bpobgyn.2017.11.005. Epub 2017 Nov 22.
本文引用的文献
1
Preservation of Fertility Potential for Gender and Sex Diverse Individuals.
Transgend Health. 2016 Jan 1;1(1):41-44. doi: 10.1089/trgh.2015.0010. eCollection 2016.
2
Presence of Germ Cells in Disorders of Sex Development: Implications for Fertility Potential and Preservation.
J Urol. 2017 Mar;197(3 Pt 2):937-943. doi: 10.1016/j.juro.2016.08.108. Epub 2016 Nov 10.
3
Coping With Diverse Sex Development: Treatment Experiences and Psychosocial Support During Childhood and Adolescence and Adult Well-Being.
J Pediatr Psychol. 2017 Jun 1;42(5):504-519. doi: 10.1093/jpepsy/jsw058.
4
Testicular Biopsy for Fertility Preservation in Prepubertal Boys with Cancer: Identifying Preferences for Procedure and Reactions to Disclosure Practices.
J Urol. 2016 Jul;196(1):219-24. doi: 10.1016/j.juro.2016.02.2967. Epub 2016 Mar 3.
5
Global Disorders of Sex Development Update since 2006: Perceptions, Approach and Care.
Horm Res Paediatr. 2016;85(3):158-80. doi: 10.1159/000442975. Epub 2016 Jan 28.
6
Tough Talk: Discussing Fertility Preservation with Adolescents and Young Adults with Cancer.
J Adolesc Young Adult Oncol. 2015 Sep;4(3):96-9. doi: 10.1089/jayao.2014.0047. Epub 2015 Jul 1.
7
Responding to Adolescents with Cancer who Refuse Sperm Banking: When "No" Should Not Be the Last Word.
J Adolesc Young Adult Oncol. 2011 Sep;1(3):114-7. doi: 10.1089/jayao.2011.0028.
8
Fertility Issues in Disorders of Sex Development.
Endocrinol Metab Clin North Am. 2015 Dec;44(4):867-81. doi: 10.1016/j.ecl.2015.07.012. Epub 2015 Sep 3.
9
The Ethics of Fertility Preservation for Paediatric Cancer Patients: From Offer to Rebuttable Presumption.
Bioethics. 2015 Nov;29(9):639-45. doi: 10.1111/bioe.12190.
10
Invisible Harm.
Narrat Inq Bioeth. 2015 Summer;5(2):122-5. doi: 10.1353/nib.2015.0056.
Zotero 插件