Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Nat Biomed Eng. 2020 Apr;4(4):381-393. doi: 10.1038/s41551-020-0525-x. Epub 2020 Apr 6.
Engineered male and female biomimetic reproductive tissues are being developed as autonomous in vitro units or as integrated multi-organ in vitro systems to support germ cell and embryo function, and to display characteristic endocrine phenotypic patterns, such as the 28-day human ovulatory cycle. In this Review, we summarize how engineered reproductive tissues facilitate research in reproductive biology, and overview strategies for making engineered reproductive tissues that might eventually allow the restoration of reproductive capacity in patients.
正在开发工程化的男性和女性仿生生殖组织，作为自主的体外单位或作为集成的多器官体外系统，以支持生殖细胞和胚胎功能，并显示特征性的内分泌表型模式，如 28 天的人类排卵周期。在这篇综述中，我们总结了工程化生殖组织如何促进生殖生物学的研究，并概述了制造工程化生殖组织的策略，这些组织最终可能允许恢复患者的生殖能力。
