Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Chem Soc Rev. 2017 Oct 30;46(21):6570-6599. doi: 10.1039/c7cs00460e.
Synthetic polypeptides from the ring-opening polymerization of N-carboxyanhydrides (NCAs) are one of the most important biomaterials. The unique features of these synthetic polypeptides, including their chemical diversity of side chains and their ability to form secondary structures, enable their broad applications in the field of gene delivery, drug delivery, bio-imaging, tissue engineering, and antimicrobials. In this review article, we summarize the recent advances in the design of polypeptide-based supramolecular structures, including complexes with nucleic acids, micelles, vesicles, hybrid nanoparticles, and hydrogels. We also highlight the progress in the chemical design of functional polypeptides, which plays a crucial role to manipulate their assembly behaviours and optimize their biomedical performances. Finally, we conclude the review by discussing the future opportunities in this field, including further studies on the secondary structures and cost-effective synthesis of polypeptide materials.
由 N-羧酸酐（NCAs）开环聚合得到的合成多肽是最重要的生物材料之一。这些合成多肽具有独特的特性，包括侧链的化学多样性和形成二级结构的能力，使其在基因传递、药物传递、生物成像、组织工程和抗菌等领域得到广泛应用。在这篇综述文章中，我们总结了基于多肽的超分子结构设计的最新进展，包括与核酸、胶束、囊泡、杂化纳米粒子和水凝胶的复合物。我们还强调了功能多肽的化学设计的进展，这对于操纵它们的组装行为和优化它们的生物医学性能起着至关重要的作用。最后，我们通过讨论该领域的未来机遇来结束综述，包括进一步研究多肽材料的二级结构和经济高效的合成。
