Littlewood J T, Gibb C, Glover V, Sandler M, Davies P T, Rose F C
Bernhard Baron Memorial Research Laboratories, Queen Charlotte's Hospital, London.
Lancet. 1988 Mar 12;1(8585):558-9. doi: 10.1016/s0140-6736(88)91353-0.
Patients with migraine who believed that red wine but not alcohol in general had a headache-provoking effect on them were challenged either with red wine or with a vodka and diluent mixture of equivalent alcohol content, both consumed cold out of dark bottles to disguise colour and flavour. The red wine, which had a negligible tyramine content, provoked a typical migraine attack in 9 of 11 such patients, whereas none of the 8 challenged with vodka had an attack. Neither red wine nor vodka provoked such episodes in other migrainous subjects or controls. These findings show that red wine contains a migraine-provoking agent that is neither alcohol nor tyramine.
那些认为红酒而非一般酒精会引发头痛的偏头痛患者，分别接受了红酒或酒精含量相当的伏特加与稀释剂混合物的激发试验，两种饮品均从深色瓶中冷藏取出，以掩盖颜色和味道。红酒中的酪胺含量可忽略不计，11名此类患者中有9名在饮用红酒后引发了典型的偏头痛发作，而8名接受伏特加激发试验的患者均未发作。红酒和伏特加在其他偏头痛患者或对照组中均未引发此类发作。这些发现表明，红酒中含有一种引发偏头痛的物质，既不是酒精也不是酪胺。
