Lucerón-Lucas-Torres Maribel, Ruiz-Grao Marta C, Pascual-Morena Carlos, Priego-Jiménez Susana, López-González María, Álvarez-Bueno Celia
Centro de Estudios Socio-Sanitarios, Grupo de Investigación Age-ABC, Universidad de Castilla-La Mancha, Cuenca, 16002, Spain.
Department of Nursing, University of Castilla-La Mancha, Campus Universitario s/n - 02071 - Albacete, Spain.
Alcohol Alcohol. 2025 Jan 19;60(2). doi: 10.1093/alcalc/agaf004.
It seems that diet is one of the main triggers of migraine; one of the most studied is alcohol, and also, over the years, red wine has been shown to trigger headaches. Therefore, this systematic review and meta-analysis aims to examine the strength of the association between wine consumption and migraine.
In this systematic review and meta-analysis, a search of MEDLINE (via PubMed), Scopus, Cochrane, and Web of Science databases was conducted to assess the association between wine consumption and migraine, covering baseline to December 2023. Pooled Odds Ratio (p-OR) were calculated using the DerSimonian and Laird methods. This study was previously registered in PROSPERO (CRD42024511115). The risk of bias was evaluated using The Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies.
Five studies were included in this systematic review, and only four of them were in the meta-analysis. Using the DerSimonian and Laird method, the p-OR for the effect of wine consumption on migraine was 0.63 (95% CI 0.36-1.09). The included studies after the risk of bias assessment showed a moderate risk of bias.
The findings of this systematic review and meta-analysis indicate that there is no conclusive evidence to support an increased or decreased risk of migraine associated with wine consumption.
饮食似乎是偏头痛的主要诱发因素之一；研究最多的因素之一是酒精，而且多年来，红酒已被证明会引发头痛。因此，本系统评价和荟萃分析旨在研究饮酒与偏头痛之间关联的强度。
在本系统评价和荟萃分析中，检索了MEDLINE（通过PubMed）、Scopus、Cochrane和科学网数据库，以评估饮酒与偏头痛之间的关联，涵盖从基线到2023年12月的数据。采用DerSimonian和Laird方法计算合并优势比（p-OR）。本研究先前已在PROSPERO（CRD42024511115）注册。使用观察性队列研究和横断面研究的质量评估工具评估偏倚风险。
本系统评价纳入了五项研究，其中只有四项纳入了荟萃分析。采用DerSimonian和Laird方法，饮酒对偏头痛影响的p-OR为0.63（95%CI 0.36-1.09）。纳入研究在进行偏倚风险评估后显示存在中度偏倚风险。
本系统评价和荟萃分析的结果表明，没有确凿证据支持饮酒会增加或降低偏头痛风险。
