Li Gang, Yang Yue, Dong Hua-Jiang, Lin Ling
Tianjin University, State Key Laboratory of Precision Measurement Technology and Instruments, Tianjin, China.
Turk Neurosurg. 2018;28(5):696-702. doi: 10.5137/1019-5149.JTN.20829-17.1.
Traumatic brain injury (TBI) is the leading cause of mortality and morbidity in children and adults throughout the world. It is urgent to ameliorate TBI damage and reduce the disability and case-fatality rate. Stem cell therapy is another medical revolution after drug and surgical medication. Mesenchymal stem cells (MSCs) are a class of cells with significant self-renewal and multi-lineage differentiation properties. They are favorable for the treatment of various diseases and injuries. It could be envisioned that MSCs transplantation may be a promising treatment for TBI. Currently, stem cell therapy has shown promising effects in the treatment of many diseases. In this article, we will review the characteristics of MSCs, MSCs for neuronal function restoration, the properties of immune-modulatory of MSCs, and the anti-apoptotic effects of MSCs, the angiogenesis effect of MSCs, and the safety issues in MSCs therapy in TBI.
创伤性脑损伤（TBI）是全球儿童和成人死亡和发病的主要原因。改善TBI损伤并降低残疾率和病死率迫在眉睫。干细胞疗法是继药物和手术治疗之后的又一次医学革命。间充质干细胞（MSCs）是一类具有显著自我更新和多向分化特性的细胞。它们有利于治疗各种疾病和损伤。可以设想，间充质干细胞移植可能是治疗TBI的一种有前景的方法。目前，干细胞疗法在许多疾病的治疗中已显示出有前景的效果。在本文中，我们将综述间充质干细胞的特性、用于神经元功能恢复的间充质干细胞、间充质干细胞的免疫调节特性、间充质干细胞的抗凋亡作用、间充质干细胞的血管生成作用以及间充质干细胞治疗TBI的安全性问题。
