Dong Huajiang, Li Gang, Shang Chongzhi, Yin Huijuan, Luo Yuechen, Meng Huipeng, Li Xiaohong, Wang Yali, Lin Ling, Zhao Mingliang
State Key Laboratory of Precision Measurement Technology and Instruments, Tianjin UniversityTianjin, China.
Laser Medicine Laboratory, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical CollegeTianjin 300192, China.
Am J Transl Res. 2018 Mar 15;10(3):901-906. eCollection 2018.
This study reports a case of a 4-year-old boy patient with abnormalities of muscle tone, movement and motor skills, as well as unstable gait leading to frequent falls. The results of the electroencephalogram (EEG) indicate moderately abnormal EEG, accompanied by irregular seizures. Based on these clinical characteristics, the patient was diagnosed with cerebral palsy (CP) in our hospital. In this study, the patient was treated with umbilical cord mesenchymal stem cell (UC-MSC) transplantation therapy. This patient received UC-MSC transplantation 3 times (5.3*10) in total. After three successive cell transplantations, the patient recovered well and showed obvious improvements in EEG and limb strength, motor function, and language expression. However, the improvement in intelligence quotient (IQ) was less obvious. These results indicate that UC-MSC transplantation is a promising treatment for cerebral palsy.
本研究报告了一例4岁男童患者，其存在肌张力、运动及运动技能异常，步态不稳导致频繁跌倒。脑电图（EEG）结果显示脑电图中度异常，并伴有不规则癫痫发作。基于这些临床特征，该患者在我院被诊断为脑瘫（CP）。在本研究中，该患者接受了脐带间充质干细胞（UC-MSC）移植治疗。该患者共接受了3次UC-MSC移植（5.3×10）。经过连续三次细胞移植后，患者恢复良好，脑电图、肢体力量、运动功能及语言表达均有明显改善。然而，智商（IQ）的改善不太明显。这些结果表明，UC-MSC移植是一种有前景的脑瘫治疗方法。
