两种定量超声方法的分析
Analysis of Two Quantitative Ultrasound Approaches.
作者信息
Muleki-Seya Pauline, Han Aiguo, Andre Michael P, Erdman John W, O'Brien William D
机构信息
1 Bioacoustics Research Laboratory, Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
2 Department of Radiology, University of California at San Diego, San Diego, CA, USA.
出版信息
Ultrason Imaging. 2018 Mar;40(2):84-96. doi: 10.1177/0161734617729159. Epub 2017 Sep 25.
There are two well-known ultrasonic approaches to extract sets of quantitative parameters: Lizzi-Feleppa (LF) parameters: slope, intercept, and midband; and quantitative ultrasound (QUS)-derived parameters: effective scatterer diameter (ESD) and effective acoustic concentration (EAC). In this study, the relation between the LF and QUS-derived parameters is studied theoretically and experimentally on ex vivo mouse livers. As expected from the theory, LF slope is correlated to ESD ([Formula: see text]), and from experimental data, LF midband is correlated to EAC ([Formula: see text]). However, LF intercept is not correlated to ESD ([Formula: see text]) nor EAC ([Formula: see text]). The unexpected correlation observed between LF slope and EAC ([Formula: see text]) results likely from the high correlation between ESD and EAC due to the inversion process. For a liver fat percentage estimation, an important potential medical application, the parameters presenting the better correlation are EAC ([Formula: see text]) and LF midband ([Formula: see text]).
有两种提取定量参数集的著名超声方法
利齐-费莱帕（LF）参数，即斜率、截距和中频带；以及定量超声（QUS）衍生参数，即有效散射体直径（ESD）和有效声浓度（EAC）。在本研究中，对离体小鼠肝脏在理论和实验上研究了LF参数与QUS衍生参数之间的关系。正如理论所预期的，LF斜率与ESD相关（[公式：见原文]），并且从实验数据来看，LF中频带与EAC相关（[公式：见原文]）。然而，LF截距与ESD（[公式：见原文]）和EAC（[公式：见原文]）均不相关。LF斜率与EAC之间观察到的意外相关性（[公式：见原文]）可能是由于反演过程中ESD与EAC之间的高度相关性所致。对于肝脏脂肪百分比估计这一重要的潜在医学应用，呈现出更好相关性的参数是EAC（[公式：见原文]）和LF中频带（[公式：见原文]）。
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