Department of Surgery, Columbia University Medical Center, New York, New York.
Ann Am Thorac Soc. 2017 Sep;14(Supplement_3):S220-S225. doi: 10.1513/AnnalsATS.201607-534MG.
This article summarizes studies in which the author has been involved over several decades, directed toward providing solutions for the three major limitations to the field of transplantation: (1) drug treatment-related complications; (2) chronic rejection; and (3) the availability of transplantable organs. The first two of these limitations may be overcome by induction of transplantation tolerance, while the third will also require a new source of organs, for which great strides are now being made in xenotransplantation through genetic engineering.
本文总结了作者几十年来参与的研究，旨在为移植领域的三大限制提供解决方案：（1）药物治疗相关并发症；（2）慢性排斥反应；（3）可移植器官的可用性。前两个限制可以通过诱导移植耐受来克服，而第三个限制还需要新的器官来源，这方面通过基因工程的异种移植现在已经取得了很大进展。
