1 Department of Medicine and.
2 Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, Colorado.
Ann Am Thorac Soc. 2017 Sep;14(Supplement_3):S233-S236. doi: 10.1513/AnnalsATS.201608-610MG.
Mucosal tissues represent surfaces that are exposed to the outside world and provide a conduit for internal and external communication. Tissues such as the intestine and the lung are lined by layer(s) of epithelial cells that, when organized in three dimensions, provide a critical barrier to the flux of luminal contents. This selective barrier is provided through the regulated expression of junctional proteins and mucins. Tissue oxygen metabolism is central to the maintenance of homeostasis in the mucosa. In some organs (e.g., the colon), low baseline Po determines tissue metabolism and results in basal expression of the transcription factor, hypoxia-inducible factor (HIF), which is enhanced after ischemia/inflammation. Recent studies have indicated that HIF contributes fundamentally to the expression of barrier-related genes and in the regulation of barrier-adaptive responses within the mucosa. Here, we briefly review recent literature on the topic of hypoxia and HIF regulation of barrier in mucosal health and during disease.
黏膜组织代表暴露于外界的表面，并为内部和外部交流提供通道。肠道和肺部等组织由一层或多层上皮细胞排列而成，当这些细胞以三维方式排列时，为腔内容物的流动提供了关键的屏障。这种选择性屏障是通过调节连接蛋白和粘蛋白的表达来实现的。组织氧代谢是维持黏膜内稳态的核心。在某些器官（例如结肠）中，低基线 Po 决定了组织代谢，并导致转录因子缺氧诱导因子（HIF）的基础表达，在缺血/炎症后增强。最近的研究表明，HIF 从根本上有助于屏障相关基因的表达，并调节黏膜内的屏障适应性反应。在这里，我们简要回顾了有关缺氧和 HIF 调节黏膜健康和疾病中屏障的最新文献。
