Zhao Jun, Shi Xuefeng, Wang Tao, Ying Chunhua, He Shaojun, Chen Yifei
Department of Respiratory Medicine, Qinghai Provincial People's Hospital, Xining, China.
Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China.
Cell Physiol Biochem. 2017;43(2):697-704. doi: 10.1159/000480655. Epub 2017 Sep 22.
BACKGROUND/AIMS: Accumulating studies have reported that IGF-1R (Insulin-like growth factor-1 receptor) is aberrantly expressed in NSCLC (non-small cell lung cancer), but the role of IGF-1R in NSCLC remains controversial. The present paper assessed the precise role of IGF-1R in NSCLC.
We comprehensively searched PubMed, EMBASE, and Web of Science in March 2017. Combined HRs and ORs were used to evaluate the prognostic and clinicopathological significance of IGF-1R in NSCLC respectively.
A total of 10 eligible studies including 8 on overall survival, and 10 on clinicopathological features were identified from the databases. The results showed that high expression of IGF-1R was associated with shorter OS (overall survival) of NSCLC patients (pooled HR 1.17,95 % CI 1.00-1.36). In addition, we found that IGF-1R was related to smoking status (OR=1.82, 95 % CI=1.35-2.44) and IGF-1R tended to be highly expressed in SCC (squamous cell carcinoma) (OR=3.40 95 % CI: 1.95-5.95).
In summary, this meta-analysis revealed that high expression of IGF-1R was associated with poor prognosis in NSCLC.
背景/目的：越来越多的研究报道胰岛素样生长因子1受体（IGF-1R）在非小细胞肺癌（NSCLC）中异常表达，但IGF-1R在NSCLC中的作用仍存在争议。本文评估了IGF-1R在NSCLC中的确切作用。
我们于2017年3月全面检索了PubMed、EMBASE和科学网。合并的风险比（HRs）和比值比（ORs）分别用于评估IGF-1R在NSCLC中的预后和临床病理意义。
从数据库中总共鉴定出10项符合条件的研究，其中8项关于总生存期，10项关于临床病理特征。结果显示，IGF-1R高表达与NSCLC患者较短的总生存期（OS）相关（合并HR 1.17，95%CI 1.00-1.36）。此外，我们发现IGF-1R与吸烟状况相关（OR=1.82，95%CI=1.35-2.44），且IGF-1R在鳞状细胞癌（SCC）中倾向于高表达（OR=3.40，95%CI：1.95-5.95）。
总之，这项荟萃分析表明IGF-1R高表达与NSCLC预后不良相关。
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