Yamaguchi Seiji, Hashimoto Hideki, Nakai Ryusuke, Takadama Hiroaki
Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai 487-0027, Japan.
Materials (Basel). 2017 Sep 24;10(10):1127. doi: 10.3390/ma10101127.
Titanium metal (Ti) and its alloys are widely used in orthopedic and dental fields. We have previously shown that acid and heat treatment was effective to introduce bone bonding, osteoconduction and osteoinduction on pure Ti. In the present study, acid and heat treatment with or without initial NaOH treatment was performed on typical Ti-based alloys used in orthopedic and dental fields. Dynamic movements of alloying elements were developed, which depended on the kind of treatment and type of alloy. It was found that the simple acid and heat treatment enriched/remained the alloying elements on Ti-6Al-4V, Ti-15Mo-5Zr-3Al and Ti-15Zr-4Nb-4Ta, resulting in neutral surface charges. Thus, the treated alloys did not form apatite in a simulated body fluid (SBF) within 3 days. In contrast, when the alloys were subjected to a NaOH treatment prior to an acid and heat treatment, alloying elements were selectively removed from the alloy surfaces. As a result, the treated alloys became positively charged, and formed apatite in SBF within 3 days. Thus, the treated alloys would be useful in orthopedic and dental fields since they form apatite even in a living body and bond to bone.
钛金属（Ti）及其合金在骨科和牙科领域有着广泛应用。我们之前已经表明，酸处理和热处理能有效地在纯钛上引入骨结合、骨传导和骨诱导性能。在本研究中，对骨科和牙科领域使用的典型钛基合金进行了有无初始氢氧化钠处理的酸处理和热处理。合金元素出现了动态变化，这取决于处理方式和合金类型。结果发现，简单的酸处理和热处理使Ti-6Al-4V、Ti-15Mo-5Zr-3Al和Ti-15Zr-4Nb-4Ta合金表面的合金元素富集/保留，导致表面电荷呈中性。因此，经处理的合金在3天内无法在模拟体液（SBF）中形成磷灰石。相反，当合金在酸处理和热处理之前先进行氢氧化钠处理时，合金表面的合金元素会被选择性去除。结果，经处理的合金带正电荷，并在3天内在SBF中形成磷灰石。因此，经处理的合金在骨科和牙科领域将很有用，因为它们即使在活体中也能形成磷灰石并与骨结合。
