Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu, Japan.
Graduate School of Engineering, Kyushu Institute of Technology, Kitakyushu, Japan.
J Biomed Mater Res B Appl Biomater. 2018 Oct;106(7):2519-2523. doi: 10.1002/jbm.b.34068. Epub 2017 Dec 23.
Hafnium (Hf) has attracted considerable attention as a component of biomedical titanium (Ti) alloys with low Young's moduli and/or shape-memory functionalities, because its cytotoxicity is as low as that of Ti. The drawback of metals is that their bone-bonding ability is generally low. It is known that apatite formation in the body is a prerequisite for bone-bonding. Although several chemical treatments have been proposed for preparing Ti for bone-bonding, there have been no similar investigations for Hf. In the present study, NaOH- and heat-treatments were applied to pure Hf and Ti-Hf alloys and their bone-bonding ability was assessed in vitro with the use of simulated body fluid (SBF). After NaOH- and heat-treatments, anatase formed on alloys with low Hf content (20-40% (atom%) Hf); mixtures of sodium titanate and hafnium titanate formed on alloys with similar Ti and Hf content (60% Hf); and hafnium oxide formed on alloys with high Hf content (80% Hf and pure Hf). Precipitates of apatite were observed on all the metals in SBF, except for the alloy with 60% Hf. We speculated that the hafnium titanate formed on this alloy had a low apatite-forming ability owing to its high negative surface charge, which inhibited P adsorption. The apatite-forming abilities of the Ti-Hf alloys strongly depended on their Hf content. The present results indicate that Hf-based materials have good potential for bone-bonding. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2519-2523, 2018.
铪（Hf）作为生物医学钛（Ti）合金的组成部分具有较低的杨氏模量和/或形状记忆功能，引起了相当大的关注，因为其细胞毒性与 Ti 相当。金属的缺点是它们的骨结合能力通常较低。已知体内磷灰石的形成是骨结合的前提。虽然已经提出了几种化学处理方法来制备用于骨结合的 Ti，但对于 Hf 尚未进行类似的研究。在本研究中，对纯 Hf 和 Ti-Hf 合金进行了 NaOH 和热处理，并使用模拟体液（SBF）评估了它们的骨结合能力。NaOH 和热处理后，在低 Hf 含量（20-40%（原子%）Hf）的合金上形成锐钛矿；在 Ti 和 Hf 含量相似（60%Hf）的合金上形成钛酸钠和铪钛酸盐的混合物；在高 Hf 含量（80%Hf 和纯 Hf）的合金上形成氧化铪。除了含 60%Hf 的合金外，所有金属在 SBF 中均观察到磷灰石沉淀物。我们推测，由于其高负表面电荷，抑制了 P 吸附，该合金上形成的钛酸铪具有较低的磷灰石形成能力。Ti-Hf 合金的磷灰石形成能力强烈依赖于其 Hf 含量。本研究结果表明，基于 Hf 的材料具有良好的骨结合潜力。©2018 Wiley Periodicals，Inc. J Biomed Mater Res Part B： Appl Biomater，106B：2519-2523，2018。
