异养培养微藻生产色素：综述。
Heterotrophic cultivation of microalgae for pigment production: A review.
机构信息
Collaborative Innovation Center of Biomass Energy, Henan Agricultural University, Henan Province, Zhengzhou 450002, China.
Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan; Department of Chemical Engineering, National Cheng Kung University, Tainan, Taiwan.
出版信息
Biotechnol Adv. 2018 Jan-Feb;36(1):54-67. doi: 10.1016/j.biotechadv.2017.09.009. Epub 2017 Sep 22.
Pigments (mainly carotenoids) are important nutraceuticals known for their potent anti-oxidant activities and have been used extensively as high end health supplements. Microalgae are the most promising sources of natural carotenoids and are devoid of the toxic effects associated with synthetic derivatives. Compared to photoautotrophic cultivation, heterotrophic cultivation of microalgae in well-controlled bioreactors for pigments production has attracted much attention for commercial applications due to overcoming the difficulties associated with the supply of CO and light, as well as avoiding the contamination problems and land requirements in open autotrophic culture systems. In this review, the heterotrophic metabolic potential of microalgae and their uses in pigment production are comprehensively described. Strategies to enhance pigment production under heterotrophic conditions are critically discussed and the challenges faced in heterotrophic pigment production with possible alternative solutions are presented.
色素（主要是类胡萝卜素）是重要的营养保健品，具有很强的抗氧化活性，被广泛用作高端保健品。微藻是天然类胡萝卜素最有前途的来源，而且没有与合成衍生物相关的毒性作用。与光合自养培养相比，在可控生物反应器中异养培养微藻生产色素的方法因其克服了与 CO 和光供应相关的困难，以及避免了开放自养培养系统中的污染问题和土地需求，因此引起了人们的广泛关注，更适合商业应用。在本综述中，全面描述了微藻的异养代谢潜力及其在色素生产中的应用。批判性地讨论了在异养条件下提高色素产量的策略，并提出了异养色素生产中面临的挑战和可能的替代解决方案。
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