UCLA Stroke Center, Los Angeles, CA, USA.
UCLA Stroke Center, Los Angeles, CA, USA; Neurovascular Imaging Research Core, UCLA Department of Neurology, Los Angeles, CA, USA.
Neuropharmacology. 2018 May 15;134(Pt B):249-258. doi: 10.1016/j.neuropharm.2017.09.032. Epub 2017 Sep 22.
Neuroimaging provides detailed information regarding the hemodynamic, metabolic and cellular parameters of cerebral ischemia (CI). Although providing just a snapshot in time, it assists in delineating the boundaries and extent of this continually evolving process, from the irreversibly damaged infarct core to the penumbral tissue, where salvage via reperfusion has been the focus of acute stroke therapies. Beyond the extent of the ischemic lesion, neuroimaging elucidates the topography and underlying mechanism of CI. Finally, based on the pathophysiological information, neuroimaging assists in the selection of optimal therapeutic strategies, from hyperacute to chronic phases of CI. Here we review different neuroimaging techniques by which the pathophysiology of cerebral ischemia can be delineated. This article is part of the Special Issue entitled 'Cerebral Ischemia'.
神经影像学提供了有关脑缺血（CI）的血液动力学、代谢和细胞参数的详细信息。尽管它只提供了一个时间点的快照，但它有助于描绘这个不断发展的过程的边界和范围，从不可逆转的损伤梗死核心到通过再灌注进行挽救的半影组织，这一直是急性卒中治疗的焦点。除了缺血性病变的范围之外，神经影像学还阐明了 CI 的拓扑结构和潜在机制。最后，基于病理生理学信息，神经影像学有助于选择从超急性到慢性 CI 阶段的最佳治疗策略。在这里，我们通过不同的神经影像学技术来回顾脑缺血的病理生理学。本文是专题“脑缺血”的一部分。
