急性脑出血的损伤机制。
Injury mechanisms in acute intracerebral hemorrhage.
机构信息
Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
出版信息
Neuropharmacology. 2018 May 15;134(Pt B):240-248. doi: 10.1016/j.neuropharm.2017.09.033. Epub 2017 Sep 22.
Abstract
Intracerebral hemorrhage (ICH) is the most common hemorrhagic stroke subtype, and rates are increasing with an aging population. Despite an increase in research and trials of therapies for ICH, mortality remains high and no interventional therapy has been demonstrated to improve outcomes. We review known mechanisms of injury, recent clinical trial results, and newly discovered signaling pathways involved in hematoma clearance. Enthusiasm remains high for methods of minimally invasive clot removal as well as pharmacologic strategies to improve recovery after ICH, both of which are currently being evaluated in clinical trials. This article is part of the Special Issue entitled 'Cerebral Ischemia'.
摘要
脑出血（ICH）是最常见的出血性中风类型，随着人口老龄化，其发病率正在上升。尽管对 ICH 的治疗方法进行了更多的研究和试验，但死亡率仍然很高，没有介入治疗被证明可以改善预后。我们回顾了已知的损伤机制、最近的临床试验结果以及新发现的与血肿清除相关的信号通路。目前正在临床试验中评估微创清除血栓的方法和改善 ICH 后恢复的药物策略，人们对这两种方法的兴趣仍然很高。本文是特刊“脑缺血”的一部分。
相似文献
1
Injury mechanisms in acute intracerebral hemorrhage.
Neuropharmacology. 2018 May 15;134(Pt B):240-248. doi: 10.1016/j.neuropharm.2017.09.033. Epub 2017 Sep 22.
2
Mechanism and Therapy of Brain Edema after Intracerebral Hemorrhage.
Cerebrovasc Dis. 2016;42(3-4):155-69. doi: 10.1159/000445170. Epub 2016 Apr 26.
3
Deferoxamine therapy for intracerebral hemorrhage.
Acta Neurochir Suppl. 2008;105:3-6. doi: 10.1007/978-3-211-09469-3_1.
4
Brain edema formation and therapy after intracerebral hemorrhage.
Neurobiol Dis. 2023 Jan;176:105948. doi: 10.1016/j.nbd.2022.105948. Epub 2022 Dec 5.
5
Intercellular cross-talk in intracerebral hemorrhage.
Brain Res. 2015 Oct 14;1623:97-109. doi: 10.1016/j.brainres.2015.04.003. Epub 2015 Apr 9.
6
Thrombin and hemin as central factors in the mechanisms of intracerebral hemorrhage-induced secondary brain injury and as potential targets for intervention.
Neurosurg Focus. 2012 Apr;32(4):E8. doi: 10.3171/2012.1.FOCUS11366.
7
Targeted temperature management after intracerebral hemorrhage (TTM-ICH): methodology of a prospective randomized clinical trial.
Int J Stroke. 2014 Jul;9(5):646-51. doi: 10.1111/ijs.12220. Epub 2014 Jan 22.
8
Tin-mesoporphyrin, a potent heme oxygenase inhibitor, for treatment of intracerebral hemorrhage: in vivo and in vitro studies.
Cell Mol Biol (Noisy-le-grand). 2000 May;46(3):597-608.
9
Pathophysiology of brain edema formation.
Neurosurg Clin N Am. 2002 Jul;13(3):371-83. doi: 10.1016/s1042-3680(02)00007-4.
10
Brain injury after intracerebral hemorrhage: the role of thrombin and iron.
Stroke. 2007 Feb;38(2 Suppl):759-62. doi: 10.1161/01.STR.0000247868.97078.10.
引用本文的文献
1
Treatment and prognosis analysis of patients with moderate-volume hypertensive basal ganglia haemorrhage using DTI-guided stereotactic puncture-based surgery.
Front Neurol. 2025 Jul 31;16:1619514. doi: 10.3389/fneur.2025.1619514. eCollection 2025.
2
Heterogeneous hematoma density predicts poor outcome in patients with supratentorial intracerebral hemorrhage after craniotomy.
BMC Neurol. 2025 Aug 13;25(1):336. doi: 10.1186/s12883-025-04348-5.
3
Perihematomal changes in glucose metabolism and cell counts in the rat collagenase model for intracerebral hemorrhage.
Sci Rep. 2025 Aug 11;15(1):29338. doi: 10.1038/s41598-025-14689-3.
4
Feasibility and Safety of Stereotactic Hematoma Aspiration via Supraorbital Keyhole Route in Patients With Basal Ganglia Spontaneous Intracerebral Hemorrhage: A Single Center Retrospective Analysis.
J Korean Med Sci. 2025 Jul 21;40(28):e159. doi: 10.3346/jkms.2025.40.e159.
5
Efficacy and safety of Shuxuening injection in intracerebral hemorrhage: a systematic review and meta-analysis.
Front Pharmacol. 2025 May 19;16:1537679. doi: 10.3389/fphar.2025.1537679. eCollection 2025.
6
Prognostic Role of Cuproptosis-Related Gene after Intracerebral Hemorrhage in Mice.
Cell Mol Neurobiol. 2025 May 22;45(1):48. doi: 10.1007/s10571-025-01571-z.
7
Ferroptosis-associated pathological injury mechanisms and therapeutic strategies after intracerebral hemorrhage.
Front Neurol. 2025 May 1;16:1508718. doi: 10.3389/fneur.2025.1508718. eCollection 2025.
8
Unraveling the Role of α2δ-1 in Cerebral Hemorrhage: Calcium Overload, Endoplasmic Reticulum Stress, and Microglial Apoptosis.
Brain Behav. 2025 May;15(5):e70499. doi: 10.1002/brb3.70499.
9
Human umbilical cord mesenchymal stem cell-derived exosomes inhibit inflammation and fibrotic scar formation after intracerebral hemorrhage.
Mol Cell Biochem. 2025 Apr 25. doi: 10.1007/s11010-025-05259-2.
10
Corticospinal tract damage on baseline CT predicts motor recovery and functional outcome in intracerebral haemorrhage.
Eur Stroke J. 2025 Apr 18:23969873251332769. doi: 10.1177/23969873251332769.
本文引用的文献
1
The intracerebral hemorrhage acutely decreasing arterial pressure trial II (ICH ADAPT II) protocol.
BMC Neurol. 2017 May 19;17(1):100. doi: 10.1186/s12883-017-0884-4.
2
CD163 Expression in Neurons After Experimental Intracerebral Hemorrhage.
Stroke. 2017 May;48(5):1369-1375. doi: 10.1161/STROKEAHA.117.016850. Epub 2017 Mar 30.
3
Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial.
Lancet. 2017 Feb 11;389(10069):603-611. doi: 10.1016/S0140-6736(16)32410-2. Epub 2017 Jan 10.
4
Acute Blood Pressure Management in Intracerebral Hemorrhage: Equipoise Resists an Attack.
Stroke. 2016 Dec;47(12):3065-3066. doi: 10.1161/STROKEAHA.116.015060. Epub 2016 Nov 15.
5
Early Erythrolysis in the Hematoma After Experimental Intracerebral Hemorrhage.
Transl Stroke Res. 2017 Apr;8(2):174-182. doi: 10.1007/s12975-016-0505-3. Epub 2016 Oct 25.
6
ICES (Intraoperative Stereotactic Computed Tomography-Guided Endoscopic Surgery) for Brain Hemorrhage: A Multicenter Randomized Controlled Trial.
Stroke. 2016 Nov;47(11):2749-2755. doi: 10.1161/STROKEAHA.116.013837. Epub 2016 Oct 6.
7
Safety and efficacy of minimally invasive surgery plus alteplase in intracerebral haemorrhage evacuation (MISTIE): a randomised, controlled, open-label, phase 2 trial.
Lancet Neurol. 2016 Nov;15(12):1228-1237. doi: 10.1016/S1474-4422(16)30234-4. Epub 2016 Oct 11.
8
Haptoglobin increases the vulnerability of CD163-expressing neurons to hemoglobin.
J Neurochem. 2016 Nov;139(4):586-595. doi: 10.1111/jnc.13720. Epub 2016 Jul 22.
9
The Safety and Feasibility of Image-Guided BrainPath-Mediated Transsulcul Hematoma Evacuation: A Multicenter Study.
Neurosurgery. 2017 Apr 1;80(4):515-524. doi: 10.1227/NEU.0000000000001316.
10
Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage.
N Engl J Med. 2016 Sep 15;375(11):1033-43. doi: 10.1056/NEJMoa1603460. Epub 2016 Jun 8.
Zotero 插件